DIODE LASER DEVICE FOR THE NON-INVASIVE MEASUREMENT OF GLYCAEMIA

• US 20110152647A1
• Filed: 01/27/2011
• Published: 06/23/2011
• Est. Priority Date: 07/30/2008
• Status: Abandoned Application

• Current Assignee: Pignolo S.p.A.
• Original Assignee: Pignolo S.p.A.
• Inventors: TROMBETTA, PIETRO, Londoni, Vittorio
• Application Number:
  US13/014,998
• Publication Number:
  US 20110152647A1
• Time in Patent Office: Days
• US Class Current: 600/316
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence

Abstract

A device has two diode laser sources in a range between 500 and 1000 nm, with a power in the range between 0.01 to 100 mW. Rays from the sources are conveyed through an optical condenser and, starting up a key, are emitted either on a nail or on the skin or even on a free blood sample. A photodiodic sensor or a CPU read the energy subtracted by glycate haemoglobin and free plasmic glucose. This value is converted into the immediate glycaemia value and appears on a device display.

Claims

1. A device to determine the glycaemia value without pricking the skin and without taking a blood sample, comprising:

two laser diode sources for emitting respective laser rays, said two laser sources being operating in a frequency range between 500 and 1000 nm, with a power in the range between 0.01 to 100 mW;

a photodiode sensor for receiving the laser rays emitted by the two laser diodes;

a four-partitioned diaphragm for housing a finger of a patient; and

a display,

wherein the use and working of said device include the following steps;

the patient puts a finger into the device, while operating a lever that opens the four-partitioned diaphragm;

upon releasing the lever, a spring lets the diaphragm close, thus determining the centred arrangement of the finger, do no matter its dimensions, on the focus of the two laser rays emitted by the two laser diodes and directed towards the photodiodes of said sensor;

the patient switches the device on, whereby the passing of the finger sets off an optical barrier that controls the starting of the two laser diodes;

the photodiodes of the sensor read the two values of the laser radiation resulting from the selective absorption of the laser rays, emitted by the two laser diodes, by the glycate haemoglobin and the free plasmic glucose present in the blood of the patient; and

an analogic stage forwards said values to a processor that, after their stabilization, digitises, normalises and extracts a high number of them, strikes an average, and, through a particular algorithm, obtains the instant value of glycaemia, that then appears on the device display,

wherein in the selective absorption of the rays, emitted by said two laser diodes, by the glycate haemoglobin and the free plasmic glucose, the glycate haemoglobin works as a control parameter, so as to obtain absolutely accurate glycaemia values, and

wherein said two values of the laser radiation resulting from the selective absorption of glycate haemoglobin and free plasmic glucose are calculated in connection with each other, whereby the measurement of the glycaemia is absolutely accurate notwithstanding the thickness and the colour of the skin and the thickness of the patient'"'"'s finger.

2. The device according to claim 1, wherein it only needs a few seconds to determine the instantaneous value of glycaemia;

in an absolutely painless and non-invading method, whereby it can be used to get several glycaemia measurements, even in a very short time range, to monitor the trend through time, to check the effectiveness of a therapy, to build glycaemic curves of newborns, children, adults and elderly people,

wherein the values are stored in sequence up to 5000 assessments and the memory can be displayed through two slide keys, and

wherein the device has a USB gate, a PC connection cable and is provided with a software to visualize and process the data.

3. The device according to claim 2, wherein it is easily activated by pressing the switch-on button, and wherein it is enough to put the patient'"'"'s finger into the device opening and start the centring system to obtain automatically, after a few seconds, the glycaemia value, that will be displayed on the device screen together with date and time of each measurement and the progressive registration number.