BARRIER COATINGS FOR FLUIDS CONTACTING MEDICAL DEVICES
First Claim
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1. An aqueous container system comprising:
- a container formed from a polymeric material;
an aqueous solution disposed within the container and comprising a polypeptide combined with a compound selected for its ability to preserve a biological activity of the polypeptide;
wherein a surface of the container is coated with a layer of material selected for its ability inhibit diffusion or permeation of the compound and gases into or through the container.
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Abstract
The invention relates to methods and materials that, for example, function to increase the barrier properties of containers including polymeric drug medication reservoirs and related containers such as infusion set tubing. Embodiments of the invention include aqueous container systems having containers coated with a composition selected to have one or more material properties including an ability to reduce the diffusion or permeation of compounds such as oxygen, carbon dioxide, and preservatives (e.g. phenol, benzyl alcohol and m-cresol) into or through a wall of the container.
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Citations
20 Claims
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1. An aqueous container system comprising:
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a container formed from a polymeric material; an aqueous solution disposed within the container and comprising a polypeptide combined with a compound selected for its ability to preserve a biological activity of the polypeptide; wherein a surface of the container is coated with a layer of material selected for its ability inhibit diffusion or permeation of the compound and gases into or through the container. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of inhibiting loss of a biological activity of a polypeptide stored within a container, comprising storing the polypeptide within an aqueous container system comprising:
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a container formed from a polymeric material; an aqueous solution disposed within the container and comprising the polypeptide combined with a compound selected for its ability to preserve a biological activity of the polypeptide; wherein a surface of the container is coated with a layer of material selected for its ability to inhibit diffusion of the compound and gases into or through the container so that the compound is maintained at a concentration sufficient to inhibit loss of a biological activity of the polypeptide. - View Dependent Claims (11, 12, 13, 14)
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15. A method of making an aqueous container system comprising:
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forming a container from a polymeric material; coating a surface of the container with a layer of material selected for its ability to function as a barrier that inhibits diffusion of compounds and gases into or through the container such that compounds can maintained at a concentration sufficient to inhibit loss of a biological activity of a polypeptide disposed within the container; disposing an aqueous solution within the container, wherein the aqueous solution comprises a polypeptide combined with a compound selected for its ability to preserve a biological activity of the polypeptide; so that an aqueous container system is made. - View Dependent Claims (16, 17, 18, 19, 20)
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Specification