THERMOCHEMICAL ABLATION SYSTEM USING HEAT FROM DELIVERY OF ELECTROPHILES
First Claim
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1. A thermochemical ablation system, comprising:
- a percutaneous fluid delivery cannula comprising a first lumen extending from a proximal portion to a distal portion, the distal portion comprising a first port in fluid communication with at least the first lumen;
a first reservoir containing a highly reactive electrophilic reagent in fluid communication with the first lumen of the percutaneous fluid delivery cannula, at least a portion of the highly reactive electrophilic reagent being deliverable out of the first port to locally generate ablation heat at a targeted site and to provide a localized residual acidic environment at the targeted site for a period of time after generation of the ablation heat; and
a real-time imaging system that monitors the distal portion of the percutaneous fluid delivery cannula and the delivery of the highly reactive electrophilic reagent.
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Abstract
Thermochemical ablation techniques may provide ablation of bodily tissue using chemical reaction energy. The chemical reaction energy is provided by chemical reactions including a highly reactive electrophilic reagent provided to a target tissue location.
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Citations
40 Claims
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1. A thermochemical ablation system, comprising:
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a percutaneous fluid delivery cannula comprising a first lumen extending from a proximal portion to a distal portion, the distal portion comprising a first port in fluid communication with at least the first lumen; a first reservoir containing a highly reactive electrophilic reagent in fluid communication with the first lumen of the percutaneous fluid delivery cannula, at least a portion of the highly reactive electrophilic reagent being deliverable out of the first port to locally generate ablation heat at a targeted site and to provide a localized residual acidic environment at the targeted site for a period of time after generation of the ablation heat; and a real-time imaging system that monitors the distal portion of the percutaneous fluid delivery cannula and the delivery of the highly reactive electrophilic reagent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method for thermochemical ablation of targeted tissue, comprising:
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delivering a highly reactive electrophilic reagent through a lumen of a percutaneous injection needle to a targeted tissue site; and reacting the delivered electrophilic reagent with nucleophiles at the targeted tissue location to locally generate ablation heat at the targeted tissue site and to provide a localized residual acidic environment at the targeted tissue site for a period of time after generation of the ablation heat. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A device to ablate bodily tissue, comprising:
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a multi-lumen thermochemical ablation cannula to sequentially infuse at least two thermochemical ablation reagents into targeted tissue proximate a distal portion of the cannula; the distal portion of the cannula comprising a plurality of fluid ports to radially disperse a first thermochemical ablation reagent into the targeted tissue to thereby pre-treat the targeted tissue and subsequently to radially disperse at least a second thermochemical ablation reagent that reacts to locally generate ablation heat in the targeted tissue proximate a distal portion of the cannula. - View Dependent Claims (32)
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- 33. A method for thermochemical ablation of targeted tissue, comprising delivering a highly reactive electrophilic reagent to a targeted tissue to generate heat in a localized area in order to ablate the targeted tissue area.
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