Device and Method for Automatically Opening and Closing a Material Container During a Lyophilization Process

• US 20110154682A1
• Filed: 12/29/2010
• Published: 06/30/2011
• Est. Priority Date: 12/30/2009
• Status: Abandoned Application

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Nail, Steven L., Kuu, Wei Y.
• Application Number:
  US12/981,001
• Publication Number:
  US 20110154682A1
• Time in Patent Office: Days
• US Class Current: 34/284
• CPC Class Codes: F26B 5/06 the process involving freezing

Abstract

A device for storing a material to be lyophilized includes a support panel, a sidewall, an opening, a cover, and at least one lifter device. The sidewall and the support panel define a storage space for accommodating a material. The opening is defined by a rim of the sidewall. The cover is removably disposed adjacent to the rim of the sidewall for closing the opening. The lifter device is disposed between the support panel and the cover and includes a reservoir and at least one movable wall. The reservoir defines a sealed cavity containing a fluid. The movable wall is in operable communication with the fluid in the sealed cavity and engaging the cover to displace the cover away from the rim when the lifter device is subject to an ambient pressure that is less than the pressure of the fluid in the sealed cavity.

Claims

1. A device for storing a material to be lyophilized, the device comprising:

a support panel;

a sidewall extending transverse to the support panel, the sidewall and the support panel defining a storage space for accommodating a material;

an opening defined by a rim of the sidewall that is spaced away from the support panel;

a cover removably disposed adjacent to the rim of the sidewall for closing the opening; and

at least one lifter device disposed between the support panel and the cover and comprising a reservoir and at least one movable wall, the reservoir defining a sealed cavity containing a fluid, the at least one movable wall in operable communication with the fluid in the sealed cavity and engaging the cover to displace the cover away from the rim when the at least one lifter device is subject to an ambient pressure that is less than the pressure of the fluid in the sealed cavity.

2. The device of claim 1, wherein the at least one lifter device comprises a cylinder and a piston slidably disposed relative to the cylinder, the cylinder defining the reservoir and the cavity, the piston defining the movable wall.

3. The device of claim 2, wherein the lifter device comprises a syringe such that the cylinder comprises a syringe tube and the piston comprises a syringe plunger.

4. The device of claim 1, wherein the at least one lifter device comprises a bellows defining the sealed cavity.

5. The device of claim 1, further comprising a gasket disposed between the cover and the rim of the sidewall adjacent to the opening for sealing the opening when the cover is the closed position.

6. The device of claim 5, wherein the gasket is attached to and extends around a perimeter portion of the cover.

7. The device of claim 5, wherein the gasket defines the at least one lifter device and comprises a tubular gasket defining the sealed cavity and a resilient sidewall portion defining the at least one movable wall.

8. The device of claim 1, wherein the sidewall comprises four sidewall panels arranged such that the sidewall has a generally square or rectangular cross-section.

9. The device of claim 8, wherein the at least one lifter device comprises four lifter devices, each lifter device disposed within a corner defined by an adjacent pair of the sidewall panels.

10. The device of claim 1, further comprising at least one member coupled to the cover and biasing the cover into the closed position.

11. The device of claim 10, wherein the at least one member comprises four springs, each spring having a first end coupled to the cover and a second end coupled to the sidewall or the support panel for biasing the cover into the closed position.

12. The device of claim 11, wherein the at least one member comprises at least one of a compression spring, an elastic cord, and a rubber band.

13. A method of facilitating the lyophilization of a material, the method comprising:

loading the material into a material container having a rim and a removable cover disposed adjacent to the rim;

loading the material container into a lyophilization chamber of a freeze drying machine while the removable cover is in a closed position engaging the rim;

lyophilizing the material;

automatically lifting the cover into an opened position spaced from the rim of the container by reducing the ambient pressure in the lyophilization chamber while lyophilizing the material to allow at least one component of the material to exhaust from the container; and

automatically returning the cover to the closed position engaging the rim of the container after lyophilizing the material by raising the ambient pressure in the lyophilization chamber.

14. The method of claim 13, wherein automatically lifting the cover into an opened position further comprises generating a lifting force with a movable wall of at least one lifter device that is disposed adjacent to the cover by expanding a fluid within a sealed cavity of the at least one lifter device.

15. The method of claim 14, wherein generating a lifting force with a movable wall comprises generating a lifting force with a piston that is at least partly slidably disposed within a cylinder by expanding a fluid within a sealed cavity of the cylinder.

16. The method of claim 14, wherein generating a lifting force with a movable wall comprises generating a lifting force with a cover that is operably connected to a bellows by expanding a fluid within a sealed cavity of the bellows.

17. The method of claim 14, wherein generating a lifting force with a movable wall comprises generating a lifting force with a resilient sidewall portion of a tubular gasket by expanding a fluid within a sealed cavity of the tubular gasket.

18. The method of claim 14, further comprising urging the cover into the closed position with a closing force that is smaller than the lifting force.

19. The method of claim 18, wherein urging the cover into the closed position comprises urging the cover into the closed position with at least one biasing member coupled to the cover and the container.

20. The method of claim 18, wherein urging the cover into the closed position comprises establishing a pressure in the lyophilization chamber that is at least equal to the pressure of the fluid in the sealed cavity of the lifter device.

21. The method of claim 18, wherein urging the cover into the closed position comprises establishing a pressure in the lyophilization chamber that is greater than the pressure of the fluid in the sealed cavity of the lifter device.

22. The method of claim 18, further comprising restoring the pressure in the lyophilization chamber after lyophilizing the material such that the closing force overcomes the lifting force and urges the cover into the closed position.