DRUG RELEASING COATINGS FOR MEDICAL DEVICES
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Abstract
The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
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Citations
189 Claims
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1-160. -160. (canceled)
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161. A method for preparing a medical device, the method comprising:
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(a) preparing a solution comprising an organic solvent, a therapeutic agent, and at least one additive, wherein a single additive of the at least one additive comprises a hydrophilic part and a hydrophobic part, and wherein the therapeutic agent is not enclosed in micelles or encapsulated in polymer particles, and wherein the solution does not include an iodine covalent bonded contrast agent, oil, or a lipid; (b) applying the solution to a medical device; and (c) drying the solution, forming a layer, wherein the ratio by weight of the at least one additive to the therapeutic agent in the layer is from about 0.05 to 100. - View Dependent Claims (162, 163, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176)
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177. A method for preparing a drug coated balloon catheter, the method comprising:
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(a) preparing a solution comprising an organic solvent, a therapeutic agent, and at least one additive, wherein the solution does not include an iodine covalent bonded contrast agent, oil, or a lipid, and (b) forming a layer on a balloon of the balloon catheter by; (i) applying the solution to the balloon in an inflated state; (ii) drying the balloon; and (iii) deflating and folding the balloon, wherein the ratio by weight of the at least one additive to the therapeutic agent in the layer is 0.05 to 100. - View Dependent Claims (178, 179, 180, 181, 182, 183, 184, 185, 186, 187, 188, 189)
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Specification