DIAGNOSTIC SKIN MAPPING BY MRS, MRI AND OTHER METHODS

• US 20110160563A1
• Filed: 02/26/2009
• Published: 06/30/2011
• Est. Priority Date: 02/26/2008
• Status: Abandoned Application

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Blümich, Bernhard P.J., Glogau, Richard G., Pines, Alexander
• Application Number:
  US12/919,183
• Publication Number:
  US 20110160563A1
• Time in Patent Office: Days
• US Class Current: 600/410
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/441 Skin evaluation, e.g. for skin disorder diagnosis
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00
• CPC Class Codes: G01N 24/08 by using nuclear magnetic resonance G01N24/12 takes precedence
• CPC Class Codes: G01R 33/50 based on the determination of relaxation times , e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences
• CPC Class Codes: G01R 33/56341 Diffusion imaging
• CPC Class Codes: G06T 2207/10088 Magnetic resonance imaging [MRI]
• CPC Class Codes: G06T 2207/30088 Skin; Dermal
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G16H 10/60 for patient-specific data, e.g. for electronic patient records
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients
• CPC Class Codes: G16H 70/60 relating to pathologies

Abstract

This invention pertains to improved methods of classifying skin types as well as improved methods for determining the appropriateness of products and evaluating methods for treating particular skin. The methods typically utilize a “skin type” database containing one or more quantitative measures (e.g., NMR data) of skin properties. The database can optionally include various qualitative measures of skin as well (e.g., Glogau scale and/or Fitzpatrick scale values).

Claims

1. A method of characterizing skin type in a human subject, said method comprising:

performing nuclear magnetic resonance (NMR) measurements at a plurality of skin depths at one or more locations on said subject; and

calculating from data provided by said NMR measurements one or more skin-type values indicative of a skin characteristic.

2. The method of claim 1, wherein said skin-type values are indicative of a Glogau and/or a Fitzpatrick scale value.

3. The method of claim 1, wherein said NMR measurements are made using a portable NMR device.

4. The method of claim 1, wherein said calculating comprises determining a Fourier transform of an NMR signal depth profile.

8. The method of claim 1, wherein said calculating comprises determining an NMR signal amplitude as a function of skin depth at a skin location.

9. The method of claim 8, wherein said calculating comprises determining an NMR signal amplitude as a function of skin depth wherein said signal amplitude as a function of skin depth defines a step.

10. The method of claim 8, wherein said calculating comprises identifying a step depth (d₀), optionally identifying a step height (Δ

f), and optionally identifying a step width (σ

).

11. The method of claim 8, wherein said skin-type values are a function of a step depth (d₀) and/or a step height (Δ

f), and/or a step width (σ

).

12. The method of claim 8, wherein said calculating comprises determining a location of a transition between cutis and subcutis and/or comprises determining a thickness of cutis and/or subcutis.

14. The method of claim 1, wherein said NMR measurements comprise measurements of one or more parameters selected from the group consisting of:

relaxation time T2 (true), relaxation time T2 (effective), relaxation time T1 (true), relaxation time T1 (effective), self-diffusion coefficient D, signal amplitude, spin modes, pulse sequence CPMG, dipolar encoded longitudinal magnetization, multiquantum build-up, multiquantum decay, diffusion coefficients, chemical shift resolved spectra, component amplitudes in chemical shift resolved spectra, and/or a mathematical function thereof.

15. The method of claim 1, further comprising outputting to a patient medical record said one or more NMR measurements and/or said one or more skin-type values.

16. The method of claim 1, further comprising outputting to a display or printer and/or storing to a computer readable medium said one or more NMR measurements and/or said one or more skin-type values.

17. The method of claim 15, wherein said patient medical records comprise one or more of the following:

Glogau value for the same skin, Fitzpatrick value for the same skin, skin thickness, skin hardness, skin water content, freckles, scaling, subject identifier, subject age, subject ethnicity, subject gender, and location of skin measurement.

5-7. -7. (canceled)

13. (canceled)

18. A method of identifying a skin type for a region of skin of a treatment subject, said method comprising:

providing a skin type database containing skin type records from a plurality of subjects;

receiving one or NMR parameters determined from said region of skin and/or skin-type values calculated from said NMR parameters;

querying said skin type database using said one or more NMR parameters and/or skin-type values to identify the skin type of said subject; and

outputting to a display or printer and/or storing to a computer readable medium a characterization of the skin type for said region of skin of said subject.

19. The method of claim 18, wherein said skin-type values are indicative of a Glogau and/or Fitzpatrick scale value.

21. The method of claim 18, wherein said NMR parameters are determined using a portable NMR device.

22. The method of claim 18, wherein said receiving comprises calculating or receiving already a calculated Fourier transform of an NMR signal depth profile.

26. The method of claim 18, wherein said receiving comprises receiving a measurement of an NMR signal amplitude as a function of skin depth at a location skin location.

27. The method of claim 26, wherein said receiving comprises receiving an NMR signal amplitude as a function of skin depth wherein said signal amplitude as a function of skin depth defines a step.

28. The method of claim 26, wherein said receiving comprises calculating or receiving already calculated a step depth (d₀), optionally a step height (Δ

f), and optionally a step width (σ

).

29. The method of claim 27, wherein said skin-type values are a function of a step depth (d₀) and/or a step height (Δ

f), and/or a step width (σ

).

30. The method of claim 18, wherein said skin type values define a location of a transition between cutis and subcutis, and/or comprise a thickness of cutis and/or subcutis.

32. The method of claim 18, wherein said NMR parameters comprise one or more parameters selected from the group consisting of:

relaxation time T2 (true), relaxation time T2 (effective), relaxation time T1 (true), relaxation time T1 (effective), self-diffusion coefficient D, signal amplitude, spin modes, pulse sequence CPMG, dipolar encoded longitudinal magnetization, multiquantum build-up, multiquantum decay, diffusion coefficients, chemical shift resolved spectra, component amplitudes in chemical shift resolved spectra, and/or a mathematical function thereof.

33. The method of claim 18, wherein at least a plurality of records comprise one or more of the following

NMR data characterizing the skin of a region of a reference subject;

skin-type values calculated from said NMR data, Glogau scale value, and Fitzpatrick scale value.

34. The method of claim 18, wherein at least a plurality of records comprise one or more of the following

a step depth (d₀), a step height (Δ

f), a step width (σ

), a location of a transition between cutis and subcutis, a thickness of cutis, a thickness of subcutis, skin thickness, skin hardness, skin water content, skin color, freckles, and scaling

35. The method of claim 18, wherein at least a plurality of records comprise one or more of the following NMR parameters:

the relaxation time T2 (true), relaxation time T2 (effective), relaxation time T1 (true), relaxation time T1 (effective), self-diffusion coefficient D, signal amplitude, spin modes, pulse sequence CPMG, dipolar encoded longitudinal magnetization, multiquantum build-up, multiquantum decay, diffusion coefficients, chemical shift resolved spectra, component amplitudes in chemical shift resolved spectra, and/or a mathematical function thereof.

36. The method of claim 18, wherein said skin type records further comprise one or more parameters selected from the group consisting of reference subject identifier, reference subject age, reference subject gender, reference subject ethnicity, and reference subject skin type sample location.

37. The method according of claim 18, wherein said receiving one or NMR parameters determined from said region of skin comprises receiving one or more skin NMR parameters selected from the group consisting of the relaxation time T2 (true), relaxation time T2 (effective), relaxation time T1 (true), relaxation time T1 (effective), self-diffusion coefficient D, signal amplitude, spin modes, pulse sequence CPMG, dipolar encoded longitudinal magnetization, multiquantum build-up, multiquantum decay, diffusion coefficients, chemical shift resolved spectra, component amplitudes in chemical shift resolved spectra, and/or a mathematical function thereof.

38. The method of claim 18, wherein said receiving further comprises receiving one or more parameters selected from the group consisting of a treatment subject identifier, a treatment subject age, a treatment subject gender, a treatment subject ethnicity, and a treatment subject skin type sample location.

39. The method of claim 18, wherein said outputting comprises outputting comprises storing to a computer readable medium selected from the group consisting of a magnetic medium, an optical medium, and a flash memory.

40. The method of claim 39, wherein said outputting comprises outputting to a patient record.

41. The method of claim 18, wherein said providing a skin type database containing skin type records from a plurality of subjects comprises accessing a remote skin type database.

20. (canceled)

23-25. -25. (canceled)

31. (canceled)

42. A machine-accessible medium that provides instructions that, if executed by a machine, will cause the machine to perform operations comprising:

receiving one or more nuclear magnetic resonance (NMR) parameters and/or skin-type values calculated from said NMR parameters and/or calculating skin-type values from said NMR parameters wherein said NMR parameters are from NMR measurements from skin at one or more locations on a subject and said skin-type values are indicative of a skin characteristic; and

determining and outputting to a display or tangible medium, a treatment plan optimized for a skin type characterization determined from said skin-type values.

43. The medium of claim 42, wherein said skin-type values are indicative of a Glogau and/or a Fitzpatrick scale value.

44. The medium of claim 42, wherein said calculating skin-type values comprises querying a skin-type skin type database to identify the skin type values characterized by said NMR parameters.

45. The medium of claim 42, wherein said NMR parameters are determined using a portable NMR device.

52. The medium of claim 42, wherein said receiving comprises calculating or receiving already calculated a step depth (d₀), optionally a step height (Δ

f), and optionally a step width (σ

).

53. The medium of claim 42, wherein said skin-type values are a function of a step depth (d₀) and/or a step height (Δ

f), and/or a step width (σ

).

54. The medium of claim 42, wherein said skin type values define a location of a transition between cutis and subcutis and/or comprise a thickness of cutis and/or subcutis.

57. The medium of claim 42, wherein said operations further comprise outputting treatment operation parameters to a device selected from the group consisting of laser, a radiofrequency device, a plasma generator, a pulsed light generator.

46-51. -51. (canceled)

55-56. -56. (canceled)

58-66. -66. (canceled)

67. A system comprising a computer processor configured to:

receive NMR data obtained from a subject'"'"'s skin and to calculate a skin-type value from said NMR data and/or to query a database storing a library of NMR skin type characterizations to return one or more skin-type values for said skin, wherein said skin-type values are indicative of a skin characteristic.

68. The system of claim 67, wherein said skin-type values are indicative of a Glogau and/or a Fitzpatrick scale value.

69. The system of claim 67, further wherein said processor or a second processor is configured to generate a treatment plan optimized for a patient skin type characterized by a said NMR data.

70. The system of claim 67, wherein said system further comprises an NMR measuring device.

71. The system of claim 67, wherein said system further comprises a portable NMR device.

72-83. -83. (canceled)

84. A method of treating a region of interest of the skin of a subject, said method comprising:

identifying a region of interest of the skin of a subject to be treated;

making one or more NMR measurements of said region to obtain NMR parameters characterizing the skin region;

calculating one or more skin-type values and/or querying an NMR skin type database with the NMR data and/or skin-type values to identify the skin type characterized by said NMR data;

calculating and outputting to a display or tangible medium, a treatment plan optimized for the skin type characterization returned from said query; and

treating said subject in accordance with said treatment plan.

85. The method of claim 84, wherein said calculating comprises analyzing a signal comprising NMR signal amplitude as a function of skin depth at a location skin location to determine a step depth (d₀), optionally a step height (Δ

f), and optionally a step width (σ

) and/or calculating comprises calculating a skin-type value that is a function of a step depth (d₀) and/or a step height (Δ

f), and/or a step width (σ

).

89. The method of claim 84, wherein said treating comprises outputting operation parameters to a device selected from the group consisting of laser, a radiofrequency device, a plasma generator, a pulsed light generator, and/or selecting a pharmaceutical and/or cosmetic regimen.

86. (canceled)

87. The method of claim 86, wherein said skin type value defines a location of a transition between cutis and subcutis, and/or comprises a thickness of cutis and/or subcutis.

88. (canceled)

90-98. -98. (canceled)

99. A method of generating a skin type database used for treating a region of skin of interest, the method comprising:

making one or more NMR measurements of a skin region of interest in a reference subject; and

storing a plurality of parameters obtained from said NMR measurement(s) and/or one or more skin-type values derived from said NMR measurement(s), in a computer readable medium to form a skin type database.

100-109. -109. (canceled)