Systems, devices, and methods including catheters configured to release ultraviolet energy absorbing agents

• US 20110160644A1
• Filed: 11/10/2010
• Published: 06/30/2011
• Est. Priority Date: 08/17/2007
• Status: Abandoned Application

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Searete LLC (Intellectual Ventures LLC)
• Inventors: Wood, Victoria Y. H., Ishikawa, Muriel Y., Smith, Michael A., Myhrvold, Nathan P., Tegreene, Clarence T., Wood, Lowell L. JR., Rivet, Dennis J., Hyde, Roderick A., Kare, Jordin T., Sweeney, Elizabeth A., Leuthardt, Eric C., Dacey, Ralph G. JR.
• Application Number:
  US12/927,295
• Publication Number:
  US 20110160644A1
• Time in Patent Office: Days
• US Class Current: 604/21
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/48 Operating or control means, e.g. from outside the body, control of sphincters
• CPC Class Codes: A61F 2/481 Acoustic or audible means
• CPC Class Codes: A61F 2/482 Electrical means
• CPC Class Codes: A61F 2002/30087 piezoelectric
• CPC Class Codes: A61F 2002/3067 for data transfer
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2250/0002 for data transfer
• CPC Class Codes: A61F 2310/0097 Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics
• CPC Class Codes: A61L 2/0011 using physical methods
• CPC Class Codes: A61L 2202/14 Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
• CPC Class Codes: A61L 2202/24 Medical instruments, e.g. endoscopes, catheters, sharps
• CPC Class Codes: A61N 1/205 for promoting a biological process
• CPC Class Codes: A61N 1/37252 Details of algorithms or data aspects of communication system, e.g. handshaking, transmitting specific data or segmenting data
• CPC Class Codes: A61N 1/3785 generated by biological activity or substance, e.g. body movement
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

Systems, devices, methods, and compositions are described for providing an actively-controllable disinfecting implantable device configured to, for example, treat or prevent an infection in a biological subject.

Claims

1. An implantable medical device, comprising:

a body structure having an inner surface defining one or more fluid-flow passageways, the body structure having a plurality of selectively actuatable waveguides elements defining at least a portion of a surface of the body structure, the selectively actuatable waveguides elements configured to guide an emitted ultraviolet energy stimulus to one or more regions proximate the surface of the body structure; and

an active agent assembly including at least one reservoir, the active agent assembly configured to deliver an ultraviolet energy absorbing agent from the at least one ultraviolet energy absorbing reservoir to one or more regions proximate the surface of the body structure.

2. The implantable medical device of claim 1, wherein one or more of the plurality of selectively actuatable waveguides elements configured to guide one or more of an electromagnetic energy stimulus, an acoustic energy stimulus, an acoustic energy stimulus, or a thermal energy stimulus.

3. The implantable medical device of claim 1, wherein the at least one reservoir includes at least one ultraviolet energy absorbing agent having an absorption spectra in a germicidal light range.

4. The implantable medical device of claim 1, wherein the at least one reservoir includes at least one ultraviolet energy absorbing agent having an absorption spectra of about 100 nanometers to about 400 nanometers.

5. The implantable medical device of claim 1, wherein the at least one reservoir includes at least one ultraviolet energy absorbing agent having an absorption spectra of about 100 nanometers to about 280 nanometers.

6. The implantable medical device of claim 1, wherein the at least one reservoir includes at least one ultraviolet energy absorbing agent having an absorption spectra of about 200 nanometers to about 290 nanometers.

7. The implantable medical device of claim 1, wherein the at least one reservoir includes at least one ultraviolet energy absorbing agent having an absorption spectra of about 280 nanometers to about 320 nanometers.

8. The implantable medical device of claim 1, wherein the at least one reservoir includes at least one ultraviolet absorbing compound.

9. The implantable medical device of claim 1, wherein the at least one reservoir includes at least one of a nucleotide composition, a nucleoside composition, or a peptide nucleic acid composition.

10. The implantable medical device of claim 1, wherein the at least one reservoir includes a synthetic nucleic acid composition.

11. The implantable medical device of claim 1, wherein the at least one reservoir includes a composition including at least one of an ultraviolet-A absorbing agent, an ultraviolet-B absorbing agent, or an ultraviolet-C absorbing agent.

12. The implantable medical device of claim 1, wherein the at least one reservoir includes a composition including at least one of sulisobenzone or thioctic acid.

13. The implantable medical device of claim 1, wherein the at least one reservoir includes a composition including at least one of 2-phenylbenzimidazole-5-sulfonic acid, cinnamic acid, ferrulic acid, salicylic acid, or methoxycinnamic acid.

14. A method, comprising:

delivering an ultraviolet energy absorbing composition to one or more regions proximate a surface of a catheter device prior to delivering a patterned energy stimulus to the one or more regions based on a detected measurand associated with biological sample proximate the one or more regions.

15. The method of claim 14, further comprising:

delivering a sterilizing ultraviolet energy stimulus to select ones of the one or more regions based on the detected measurand.

16. A method, comprising:

delivering an ultraviolet energy absorbing composition to one or more regions proximate at least one of an outer surface or an inner surface of an implanted portion of a catheter device prior to selectively energizing the one or more regions in response to a real-time detected spectral information associated with a microbial presence within the one or more regions.

17. The method of claim 16, further comprising:

delivering a sterilizing stimulus to select ones of the one or more regions in response to the real-time detected spectral information associated with the microbial presence within the one or more regions.