METHOD FOR PROVIDING PROGRESSIVE THERAPY FOR THROMBUS MANAGEMENT
First Claim
1. A method for providing progressive therapy for thrombus management in blood vessels, the method comprising:
- identifying a thrombus within a blood vessel;
inserting an expandable reperfusion device within the blood vessel to the location of the thrombus,wherein the expandable reperfusion device comprises an expandable reperfusion scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to reduce protrusion of the thrombus within the reperfusion scaffold, thereby increasing a diameter of a flow path established by the reperfusion scaffold;
deploying the reperfusion device within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing one or more blood flow channels through the thrombus,wherein the one or more blood flow channels facilitate natural lysis of the thrombus;
removing the reperfusion device;
inserting an expandable thrombus removal device within the blood vessel to the location of the thrombus,wherein the expandable thrombus removal device comprises an expandable removal scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to allow thrombus penetration within the cells, thereby facilitating engagement of the thrombus by the removal scaffold;
deploying the thrombus removal device within a remaining portion of the thrombus, thereby engaging the remaining portion of the thrombus;
extracting the remaining portion of the thrombus engaged by the thrombus removal device from the blood vessel; and
removing the thrombus removal device.
3 Assignments
0 Petitions
Accused Products
Abstract
Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
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Citations
21 Claims
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1. A method for providing progressive therapy for thrombus management in blood vessels, the method comprising:
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identifying a thrombus within a blood vessel; inserting an expandable reperfusion device within the blood vessel to the location of the thrombus, wherein the expandable reperfusion device comprises an expandable reperfusion scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to reduce protrusion of the thrombus within the reperfusion scaffold, thereby increasing a diameter of a flow path established by the reperfusion scaffold; deploying the reperfusion device within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing one or more blood flow channels through the thrombus, wherein the one or more blood flow channels facilitate natural lysis of the thrombus; removing the reperfusion device; inserting an expandable thrombus removal device within the blood vessel to the location of the thrombus, wherein the expandable thrombus removal device comprises an expandable removal scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to allow thrombus penetration within the cells, thereby facilitating engagement of the thrombus by the removal scaffold; deploying the thrombus removal device within a remaining portion of the thrombus, thereby engaging the remaining portion of the thrombus; extracting the remaining portion of the thrombus engaged by the thrombus removal device from the blood vessel; and removing the thrombus removal device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for providing progressive therapy for thrombus management, the method comprising:
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inserting an expandable reperfusion device within an occluded blood vessel having a thrombus; positioning the expandable reperfusion device to span at least a portion of a length of the thrombus; wherein the expandable reperfusion device comprises a self-expanding reperfusion scaffold having a plurality of interconnected struts that form cells sized and configured to inhibit protrusion of the thrombus into the reperfusion scaffold, thereby increasing a diameter of a flow path established by the reperfusion scaffold; deploying the reperfusion device within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing blood flow through the occluded blood vessel, wherein the established blood flow facilitates natural lysis of the thrombus; macerating the thrombus; wherein at least one of the natural lysis and the maceration fragment the thrombus until only a portion of the thrombus remains; removing the reperfusion device; inserting a thrombus removal device within the blood vessel to span at least a portion of a length of the remaining thrombus, wherein the thrombus removal device comprises a self-expanding removal scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to allow thrombus protrusion within the cells, thereby facilitating engagement of the remaining thrombus by the removal scaffold; deploying the thrombus removal device within the remaining thrombus to engage the remaining thrombus; and removing the thrombus removal device, thereby extracting the remaining thrombus. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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Specification