SYSTEM FOR PROVIDING PROGRESSIVE THERAPY FOR THROMBUS MANAGEMENT
First Claim
1. A system for providing progressive therapy for clot management, comprising:
- a microcatheter;
a first expandable tip assembly comprising a first elongate member and a first self-expanding scaffold,wherein the first self-expanding scaffold comprises open cells formed by a pattern of struts and bridges, wherein said cells have a cell size configured to hinder penetration of clot material within the scaffold, thereby increasing an amount of blood flow through the scaffold; and
a second expandable tip assembly comprising a second elongate member and a second self-expanding scaffold,wherein the second self-expanding scaffold comprises open cells formed by a pattern of struts and bridges, wherein said cells have a cell size larger than the cell size of the first self-expanding scaffold, wherein said cell size of the second self-expanding scaffold are configured to enhance penetration of clot material within scaffold to facilitate capture of the thrombus.
3 Assignments
0 Petitions
Accused Products
Abstract
Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
228 Citations
22 Claims
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1. A system for providing progressive therapy for clot management, comprising:
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a microcatheter; a first expandable tip assembly comprising a first elongate member and a first self-expanding scaffold, wherein the first self-expanding scaffold comprises open cells formed by a pattern of struts and bridges, wherein said cells have a cell size configured to hinder penetration of clot material within the scaffold, thereby increasing an amount of blood flow through the scaffold; and a second expandable tip assembly comprising a second elongate member and a second self-expanding scaffold, wherein the second self-expanding scaffold comprises open cells formed by a pattern of struts and bridges, wherein said cells have a cell size larger than the cell size of the first self-expanding scaffold, wherein said cell size of the second self-expanding scaffold are configured to enhance penetration of clot material within scaffold to facilitate capture of the thrombus. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A system for providing progressive therapy for clot management, the system comprising:
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a microcatheter configured to be inserted within an occluded blood vessel to a location of the thrombus; a temporary expandable reperfusion device configured to be inserted through the microcatheter to the location of the thrombus, wherein the expandable reperfusion device comprises a self-expanding scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to hinder penetration of the thrombus into the expandable scaffold, thereby increasing a diameter of a flow path established by the expandable scaffold; and a temporary expandable thrombus removal device configured to be inserted through the microcatheter to the location of the thrombus, wherein the expandable thrombus removal device comprises a self-expanding scaffold having a plurality of interconnected struts that form cells having a cell size that is sized and configured to facilitate thrombus protrusion within the cells, thereby increasing engagement of the thrombus by the expandable scaffold. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A system for providing progressive therapy for clot management, comprising:
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a microcatheter; and a variable-stiffness, laser-cut hypotube having a lumen sized and adapted to receive a guidewire, a distal portion of the hypotube having a greater flexibility than the proximal portion to facilitate introduction within tortuous cerebral vasculature; an expandable and reconstrainable scaffold coupled to the distal end of the hypotube, the scaffold being adapted to radially self-expand from a non-expanded configuration to an expanded configuration upon unsheathing of the scaffold and to transition from the expanded configuration to the non-expanded configuration upon re-sheathing of the scaffold; wherein the scaffold comprises a laser cut tube; wherein the scaffold comprises an open distal end without a distal embolic protection member or device; wherein a proximal end of the scaffold comprises a cut-out section adapted to facilitate re-sheathing of the scaffold; wherein the scaffold comprises a plurality of open cells defined by struts and connected by bridges; and wherein the open cells are sized to promote at least one of vessel reperfusion or thrombus removal. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22)
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Specification