Antigen-binding proteins that inhibit superantigens for the treatment of skin diseases
First Claim
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1. An antigen-binding protein for use in the treatment of a skin disease, wherein the antigen-binding protein is an inhibitor of a superantigen.
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Abstract
The present invention relates to superantigen-specificantigen-binding proteins comprising an immunoglobulin-derived variable domain that comprises a complete antigen binding site for an epitope on the superantigen in a single polypeptide chain. The antigen-binding proteins of the invention may be used in the treatment skin diseases. The antigen-binding proteins of the invention may be used in compositions for topical administration.
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Citations
15 Claims
- 1. An antigen-binding protein for use in the treatment of a skin disease, wherein the antigen-binding protein is an inhibitor of a superantigen.
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12. An antigen-binding protein comprising an amino acid sequence that comprises 4 framework regions, FR1 to FR4, and 3 complementarity determining regions, CDR1 to CDR3, that are operably linked in the order FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4, wherein:
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(a) the CDR1 has an amino acid sequence as presented in SEQ ID NO;
72 or an amino acid sequence that differs from SEQ ID NO;
72 in one or two of the amino acid residues;(b) the CDR2 has an amino acid sequence having at least 80% sequence identity with an amino acid sequence as presented in SEQ ID NO;
139; and
,(c) the CDR3 is an amino acid sequence having at least 80% sequence identity with an amino acid sequence as presented in SEQ ID NO;
206; and
,wherein each of the framework regions has at least 50% amino acid identity with the framework amino acid sequence of any one of SEQ ID NO;
1-4.- View Dependent Claims (13, 15)
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14. (canceled)
Specification