Cyclopamine Analogues and Methods of Use Thereof
2 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
-
Citations
40 Claims
-
1-32. -32. (canceled)
- 33. A process comprising contacting a first compound of formula 2:
Specification