IRRITATION-REDUCING OCULAR IONTOPHORESIS DEVICE
First Claim
1. An ocular iontophoresis device for delivering medication to an eye, comprising;
- an outer sidewall, the outer sidewall having a proximal end and a distal end, the distal end of the outer sidewall configured to engage the eye for delivery of the medication;
an inner sidewall, the inner sidewall having a proximal end and a distal end, the distal end of the inner sidewall configured to engage the eye for delivery of the medication, wherein the inner sidewall has a diameter less than a diameter of the outer sidewall;
an active electrode coupling the proximal ends of the outer and inner sidewalls;
wherein the active electrode comprising;
an electrically conductive layer; and
a protective layer coupled to the electrically conductive layer, the protective layer reacting significantly less than the conductive layer during iontophoretic delivery of the medication; and
the outer sidewall, the inner sidewall, and the protective layer of the active electrode defining a reservoir configured to store the medication.
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Accused Products
Abstract
The invention provides an ocular iontophoresis device for delivering medication, the device comprising a medication reservoir suitable for being positioned on the eye, at least one medication in solution in the reservoir, an active electrode disposed in the reservoir, and a passive electrode, the device including at least one medication dissolved in non-saline water, the said solution having a lying in the range 6.5 to 8.5, the medication having a pKa lying in the range about 5.5 to about 9.5 and includes an active principle which is associated with an additive, such as a dendrimer, a polymer, a nanoparticle, a microsphere, a liposome, or an emulsion, and having an ionic form of valency greater than or equal to 1.
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Citations
19 Claims
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1. An ocular iontophoresis device for delivering medication to an eye, comprising;
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an outer sidewall, the outer sidewall having a proximal end and a distal end, the distal end of the outer sidewall configured to engage the eye for delivery of the medication; an inner sidewall, the inner sidewall having a proximal end and a distal end, the distal end of the inner sidewall configured to engage the eye for delivery of the medication, wherein the inner sidewall has a diameter less than a diameter of the outer sidewall; an active electrode coupling the proximal ends of the outer and inner sidewalls; wherein the active electrode comprising; an electrically conductive layer; and a protective layer coupled to the electrically conductive layer, the protective layer reacting significantly less than the conductive layer during iontophoretic delivery of the medication; and the outer sidewall, the inner sidewall, and the protective layer of the active electrode defining a reservoir configured to store the medication. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification