Substrates for nitric oxide releasing devices

• US 20110166536A1
• Filed: 11/17/2010
• Published: 07/07/2011
• Est. Priority Date: 10/30/2007
• Status: Active Grant

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Inventors: Stordal, Leif T., Ishikawa, Muriel Y., Wood, Lowell L. JR., Hyde, Roderick A.
• Granted Patent: US 10,080,823 B2
• Time in Patent Office: Days
• US Class Current: 604/304
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61L 2300/114 Nitric oxide, i.e. NO
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

The present disclosure relates to substrates associated with nitric oxide.

Claims

1-138. -138. (canceled)

139. An article comprising:

at least one backing sheet having at least one portion that is at least partially light permeable; and

at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

140. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet having at least one portion that is at least partially light permeable and at least one portion that is at least partially impermeable to nitric oxide.

141. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet having at least one at least partially light impermeable removable portion that covers at least one portion that is at least partially light permeable.

142. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet associated with at least one therapeutic agent and having at least one portion that is at least partially light permeable.

143. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet having at least one portion that is at least partially light permeable and at least one recessed area for containing nitric oxide.

144. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet having at least one portion that is at least partially light permeable and at least one adhesive portion for containing nitric oxide.

145. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet having at least one portion that is at least partially light permeable and at least one nitric oxide permeable portion for passing nitric oxide.

146. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet associated with at least one sensor and having at least one portion that is at least partially light permeable.

147. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet associated with at least one microbe detector and having at least one portion that is at least partially light permeable.

148. The article of claim 139, wherein the at least one backing sheet having at least one portion that is at least partially light permeable comprises:

at least one backing sheet associated with at least one user interface and having at least one portion that is at least partially light permeable.

149. The article of claim 139, wherein the at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

at least one photolyzable nitric oxide donor coat associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

150. The article of claim 139, wherein the at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

at least one photolyzable nitric oxide donor composition associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

151. The article of claim 139, wherein the at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

at least one polymerized photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

152. The article of claim 139, wherein the at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

at least one photolyzable nitric oxide donor associated with at least one recessed area of the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

153. The article of claim 139, wherein the at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

at least one photolyzable nitric oxide donor associated with at least one adhesive portion of the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

154. The article of claim 139, wherein the at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide via at least one nitric oxide permeable portion in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

155. A kit comprising:

at least one article with at least one backing sheet having at least one portion that is at least partially light permeable and at least one photolyzable nitric oxide donor associated with the at least one backing sheet and operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable; and

at least one handholdable light source configured for irradiating the at least one article for releasing nitric oxide.

156. A method for fabricating an article comprising:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

157. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable and having at least one portion that is at least partially impermeable to nitric oxide with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

158. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one at least partially light impermeable removable portion; and

linking the at least one backing sheet with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

159. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one therapeutic agent and at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

160. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable and having at least one recessed area for containing nitric oxide with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

161. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable and having at least one adhesive portion for containing nitric oxide with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

162. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable and having at least one nitric oxide permeable portion for passing nitric oxide with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

163. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one sensor; and

linking the at least one backing sheet with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

164. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one microbe detector; and

linking the at least one backing sheet with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

165. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one user interface; and

linking the at least one backing sheet with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

166. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor coat operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

167. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor composition operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

168. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one polymerized photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

169. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking with at least one recessed area of at least one backing sheet having at least one portion that is at least partially light permeable, at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

170. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking with at least one adhesive portion of at least one backing sheet having at least one portion that is at least partially light permeable, at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

171. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide via at least one nitric oxide permeable portion in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

172. The method of claim 156, wherein the linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable comprises:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light from at least on handholdable light source received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

173. Non-transitory computer readable media bearing one or more processor executable instructions for facilitating operations comprising:

linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

174. A system comprising:

means for linking at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.

175. A system comprising:

circuitry configured for facilitating linking of at least one backing sheet having at least one portion that is at least partially light permeable with at least one photolyzable nitric oxide donor operable to release nitric oxide in response to light received via the at least one portion of the at least one backing sheet that is at least partially light permeable.