INSULIN RESISTANCE EVALUATION SUPPORTING SYSTEM, INSULIN RESISTANCE EVALUATION SUPPORTING METHOD, AND COMPUTER PROGRAM PRODUCT

• US 20110166792A1
• Filed: 12/28/2010
• Published: 07/07/2011
• Est. Priority Date: 06/30/2008
• Status: Abandoned Application

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Takahata, Takayuki
• Application Number:
  US12/979,985
• Publication Number:
  US 20110166792A1
• Time in Patent Office: Days
• US Class Current: 702/19
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G16H 50/50 for simulation or modelling of medical disorders
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

The present invention provides an insulin resistance evaluation supporting system, an insulin resistance evaluation supporting method, and a computer program product that can reduce the burden on a subject necessary to estimate biological information relating to the insulin resistance compared with that in conventional examples. An insulin resistance evaluation supporting system 1 includes an input/output interface 11f that receives input of information relating to a glucose concentration, an insulin concentration, and a free fatty acid concentration in blood obtained by measuring the subject, a CPU 11a that estimates a glucose uptake rate of the subject based on the information relating to the glucose concentration, the insulin concentration, and the free fatty acid concentration in the blood whose input has been received, and an image output interface 11g that outputs the estimated glucose uptake rate.

Claims

1. An insulin resistance evaluation supporting system for supporting evaluation of insulin resistance of a subject, comprising:

an input section that receives input of information relating to a glucose concentration, an insulin concentration, and a free fatty acid concentration in blood obtained by measuring the subject; and

an estimating section that estimates a glucose uptake rate of the subject based on the information relating to the glucose concentration, the insulin concentration, and the free fatty acid concentration in the blood whose input has been received by the input section.

2. The insulin resistance evaluation supporting system according to claim 1, wherein the estimating section comprises:

a first estimating section that estimates a value according to a glucose transporter appearance amount based on the information relating to the insulin concentration and the free fatty acid concentration in the blood; and

a second estimating section that estimates a glucose uptake rate based on the value according to the glucose transporter appearance amount estimated by the first estimating section and the glucose concentration in the blood.

3. The insulin resistance evaluation supporting system according to claim 2, wherein the first estimating section comprises:

a third estimating section that estimates a fatty acyl-coenzyme A complex concentration based on the information relating to the free fatty acid concentration in the blood; and

a fourth estimating section that estimates the value according to the glucose transporter appearance amount based on the insulin concentration in the blood and the fatty acyl-coenzyme A complex concentration estimated by the third estimating section.

4. The insulin resistance evaluation supporting system according to claim 3, wherein the estimating section further comprises:

a fifth estimating section that estimates an intracellular pyruvic acid concentration based on the glucose uptake rate estimated by the second estimating section;

a sixth estimating section that estimates an intracellular acetyl coenzyme concentration based on the fatty acyl-coenzyme A complex concentration estimated by the third estimating section and the pyruvic acid concentration estimated by the fifth estimating section; and

an adjusting section that adjusts a production rate of an acetyl coenzyme produced from a fatty acyl-coenzyme A complex based on the acetyl coenzyme concentration estimated by the sixth estimating section; and

the sixth estimating section again estimates the acetyl coenzyme concentration based on the production rate of the acetyl coenzyme after the adjustment by the adjusting section.

5. The insulin resistance evaluation supporting system according to claim 2,

wherein the input section further receives input of information relating to a muscle amount of the subject,

the second estimating section estimates a glucose uptake rate per unit muscle amount of the subject based on the value according to the glucose transporter appearance amount estimated by the first estimating section and the glucose concentration in the blood, and

the estimating section estimates a glucose uptake rate per unit weight of the subject based on the glucose uptake rate per unit muscle amount of the subject estimated by the second estimating section and the information relating to the muscle amount of the subject whose input has been received by the input section.

6. The insulin resistance evaluation supporting system according to claim 1,

wherein the estimating section repeats a process that, in production of a plurality of substances relating to a change from glucose to pyruvic acid in a living body, acquires amounts of the substances produced in a specific period of time based on concentrations of the substances before the production, acquires concentrations of the substances after the specific period of time by reflecting the amounts of the respective substances produced on the concentrations of the substances before the production, and estimates the glucose uptake rate based on the acquired concentrations of the substances.

7. The insulin resistance evaluation supporting system according to claim 6, wherein the estimating section determines whether or not the glucose uptake rate reaches a steady state, and repeats the process that acquires the concentrations of the substances until it is determined that the glucose uptake rate reaches a steady state.

8. The insulin resistance evaluation supporting system according to claim 6,

wherein the input section receives input of information relating to a glucose concentration, an insulin concentration, and a free fatty acid concentration in blood in a fasted state of the subject, and

the estimating section comprises:

a first glucose uptake rate estimating section that acquires concentrations of the substances in the fasted state based on the information relating to the glucose concentration, the insulin concentration, and the free fatty acid concentration in the blood whose input has been received by the input section, and estimates a glucose uptake rate in the fasted state based on the acquired concentrations of the substances; and

a second glucose uptake rate estimating section that acquires concentrations of the substances when the insulin concentration is at a predetermined value, based on the concentrations of the substances in the fasted state acquired by the first glucose uptake rate estimating section, and estimates a glucose uptake rate when the insulin concentration is at the predetermined value, based on the acquired concentrations of the substances.

9. The insulin resistance evaluation supporting system according to claim 1, further comprising an output section that outputs the glucose uptake rate estimated by the estimating section.

10. The insulin resistance evaluation supporting system according to claim 1, further comprising:

an insulin resistance estimating section that estimates insulin resistance of the subject based on information relating to the glucose uptake rate estimated by the estimating section; and

an output section that outputs a result of the estimation by the insulin resistance estimating section.

11. An insulin resistance evaluation supporting method for supporting evaluation of insulin resistance of a subject using a computer provided with an input device, comprising the steps of:

receiving from the input device, input of information relating to a glucose concentration, an insulin concentration, and a free fatty acid concentration in blood obtained by measuring the subject; and

estimating, using the computer, a glucose uptake rate of the subject based on the information relating to the glucose concentration, the insulin concentration, and the free fatty acid concentration in the blood whose input has been received from the input device.

12. The insulin resistance evaluation supporting method according to claim 11, wherein the step of estimating a glucose uptake rate of the subject comprises the steps of:

estimating, using the computer, a value according to a glucose transporter appearance amount based on the information relating to the insulin concentration and the free fatty acid concentration in the blood; and

estimating, using the computer, a glucose uptake rate based on the estimated value according to the glucose transporter appearance amount and the glucose concentration in the blood.

13. A computer program product for enabling a computer provided with an input device comprising:

a computer readable medium, and

software instructions, on the computer readable medium, for enabling the computer to perform predetermined operations comprising;

receiving from the input device, input of information relating to a glucose concentration, an insulin concentration, and a free fatty acid concentration in blood obtained by measuring a subject; and

estimating a glucose uptake rate of the subject based on the glucose concentration, the insulin concentration, and the free fatty acid concentration in the blood whose input has been received using the input device.

14. The computer program product according to claim 13, wherein

the step of estimating a glucose uptake rate of the subject comprises the steps of:

estimating a value according to a glucose transporter appearance amount based on the information relating to the insulin concentration and the free fatty acid concentration in the blood; and

estimating a glucose uptake rate based on the estimated value according to the glucose transporter appearance amount and the glucose concentration in the blood.