Conversion of Nitrogen Dioxide (NO2) to Nitric Oxide (NO)
First Claim
1. An apparatus for converting nitrogen dioxide to nitric oxide comprisinga receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent,wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
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Accused Products
Abstract
Various systems, devices, NO2 absorbents, NO2 scavengers and NO2 recuperator for generating nitric oxide are disclosed herein. According to one embodiment, an apparatus for converting nitrogen dioxide to nitric oxide can include a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
59 Citations
25 Claims
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1. An apparatus for converting nitrogen dioxide to nitric oxide comprising
a receptacle including an inlet, an outlet, a surface-active material coated with an aqueous solution of ascorbic acid and an absorbent, wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material and the absorbent such that nitrogen dioxide in the gas flow is converted to nitric oxide.
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4. A method of providing a therapeutic amount of nitric oxide to a mammal comprising:
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diffusing nitrogen dioxide into a gas flow; exposing the nitrogen dioxide to a surface-active material coated with ascorbic acid and an asorbent to eliminate the by-products of ascorbic acid oxidation; and transporting the nitric oxide in a therapeutic amount to a mammal.
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5. A system of delivering a therapeutic amount of nitric oxide to a mammal comprising
a gas source of nitric oxide; - and a NO2 scavenger selected from the group consisting of proline and diphenylamine.
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6. A recuperator for converting nitrogen dioxide into nitric oxide comprising:
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an exit shell including an outlet; an inside shell wherein the inside shell includes perforated inner and outer tubes with fixed annulus; a surface-active material coated with an aqueous solution of ascorbic acid, an absorbent and a top cap including an inlet wherein the inlet is configured to receive a gas flow and fluidly communicate the gas flow to the outlet through the surface-active material such that nitrogen dioxide in the gas flow is converted to nitric oxide. - View Dependent Claims (7)
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8. A system for delivering nitric oxide to a patient, comprising:
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a gas source of nitrogen dioxide, dinitrogen tetraoxide, or nitric oxide; a first device having an inlet, an outlet, and a porous solid matrix positioned between the inlet and the outlet, wherein the porous solid matrix is coated with an aqueous solution of an antioxidant, and wherein the inlet is configured to receive a gas flow from the source and fluidly communicate the gas flow to the outlet through the porous solid matrix to convert nitrogen dioxide in the gas flow into nitric oxide; and a recuperator coupled to the outlet of the first device, the recuperator converting nitrogen dioxide into nitric oxide prior to delivery to the patient. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method of sampling NO and NO2 gas in a NO delivery system comprising
obtaining a sample of gas; -
diluting the sample of gas with air; and measuring the amount of NO and NO2 gas with a gas analyzer. - View Dependent Claims (21, 22, 23, 24, 25)
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Specification