SAMPLE CHARACTERIZATION BASED ON AC MEASUREMENT METHODS
First Claim
1. A method, comprising:
- providing an electrochemical test strip with a mediator system that generates a linear faradic response at a low applied potential difference;
introducing blood to the mediator system and in contact with electrodes of the test strip;
applying an alternating current excitation signal as a potential difference between electrodes of the test strip and across the blood, wherein the alternating current excitation signal includes a low frequency signal and a high frequency signal that has a higher frequency than the low frequency signal; and
determining glucose concentration of the blood, wherein said determining glucose concentration includesmeasuring a low frequency response to the low frequency signal,measuring a high frequency response to the high frequency signal,estimating the glucose concentration based on the low frequency response, andcorrecting the glucose concentration for one or more error causing variables based on the high frequency response.
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Abstract
One aspect concerns a technique for detecting analyte concentrations, such as glucose concentrations, in blood or other bodily fluids. This technique utilizes an electrochemical test strip that includes a mediator system that generates a linear faradic response at relatively low applied potential differences. An alternating current excitation signal is applied to blood in the test strip. The alternating current excitation signal includes a low frequency signal and a high frequency signal that has a higher frequency than the low frequency signal. The glucose concentration is determined by measuring a low frequency response to the low frequency signal, measuring a high frequency response to the high frequency signal, estimating the glucose concentration based on the low frequency response, and correcting the glucose concentration for one or more error-causing variables based on the high frequency response.
87 Citations
24 Claims
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1. A method, comprising:
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providing an electrochemical test strip with a mediator system that generates a linear faradic response at a low applied potential difference; introducing blood to the mediator system and in contact with electrodes of the test strip; applying an alternating current excitation signal as a potential difference between electrodes of the test strip and across the blood, wherein the alternating current excitation signal includes a low frequency signal and a high frequency signal that has a higher frequency than the low frequency signal; and determining glucose concentration of the blood, wherein said determining glucose concentration includes measuring a low frequency response to the low frequency signal, measuring a high frequency response to the high frequency signal, estimating the glucose concentration based on the low frequency response, and correcting the glucose concentration for one or more error causing variables based on the high frequency response. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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Specification