MODULAR FABRICATION SYSTEMS AND METHODS
First Claim
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1. A method of fabricating a living three-dimensional structure, said method comprising:
- providing a data set representing a living three-dimensional structure to be fabricated;
providing one or more printable compositions including a composition comprising a hydrogel comprising seeded cells; and
printing the one or more compositions onto a substrate in layers in a pattern in accordance with the data set suitable to fabricate the living three-dimensional structure without the need to provide a negative template;
wherein the printable composition is capable of (i) bonding between printed layers, (ii) holding its shape against gravity, and (iii) cross-linking slowly enough to prevent cell and material shearing during printing.
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Abstract
The present invention relates to an article fabrication system having a plurality of material deposition tools containing one or more materials useful in fabricating the article, and a material deposition device having a tool interface for receiving one of the material deposition tools. A system controller is operably connected to the material deposition device to control operation of the material deposition device. Also disclosed is a method of fabricating an article using the system of the invention and a method of fabricating a living three-dimensional structure.
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Citations
19 Claims
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1. A method of fabricating a living three-dimensional structure, said method comprising:
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providing a data set representing a living three-dimensional structure to be fabricated; providing one or more printable compositions including a composition comprising a hydrogel comprising seeded cells; and printing the one or more compositions onto a substrate in layers in a pattern in accordance with the data set suitable to fabricate the living three-dimensional structure without the need to provide a negative template; wherein the printable composition is capable of (i) bonding between printed layers, (ii) holding its shape against gravity, and (iii) cross-linking slowly enough to prevent cell and material shearing during printing. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification