ORTHOVOLTAGE RADIOSURGERY
First Claim
1. A method of treating an eye with radiotherapy, comprising:
- emitting a first x-ray beam, having a maximal energy, toward a target in an eye from an x-ray source located from a first position relative to the target, the x-ray source having an anode with a non-zero size;
the first x-ray beam being configured such that a first beamspot at the target in the eye resulting from the first x-ray beam emission has a cross-sectional dimension that is no more than about 10% greater than a cross-sectional dimension of a second beamspot at the target;
the second beamspot resulting from a second x-ray beam, having the same maximal energy as the first x-ray beam, emitted from the x-ray source, at the first position, having a point-source anode.
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Accused Products
Abstract
A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.
111 Citations
20 Claims
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1. A method of treating an eye with radiotherapy, comprising:
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emitting a first x-ray beam, having a maximal energy, toward a target in an eye from an x-ray source located from a first position relative to the target, the x-ray source having an anode with a non-zero size; the first x-ray beam being configured such that a first beamspot at the target in the eye resulting from the first x-ray beam emission has a cross-sectional dimension that is no more than about 10% greater than a cross-sectional dimension of a second beamspot at the target; the second beamspot resulting from a second x-ray beam, having the same maximal energy as the first x-ray beam, emitted from the x-ray source, at the first position, having a point-source anode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of treating an eye with radiotherapy, comprising:
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emitting, from an x-ray source toward a target region in an eye, a first collimated x-ray beam having a beam axis, so as to administer a radiation dose to a target area of the target region, the x-ray source having a maximal energy, an anode with a non-zero size, the x-ray source being located at a first position relative to the target region during the emitting, and the first beam having; (a) a beam cross-section that is perpendicular to the beam axis, the cross-section having a centroid and a dimension defining a radial direction outward from the centroid; (b) a maximal dose region about the centroid having a maximum dose intensity; and (c) an outer dose drop-off region having a decreasing dose intensity distribution outward in the radial direction and extending to a delimiting dimension defined by a dose intensity of 20% of the maximum dose intensity; wherein the beam is further configured so that a first beamspot at the target area in the eye resulting from the emitting the first beam has a delimiting dimension that is no more than about 10% greater than a delimiting dimension of a second beamspot at the target area, which second beamspot would result from a second collimated x-ray beam, having the same maximum dose intensity as the first beam, emitted from the x-ray source, at the first position, having a point-source anode and the same maximal energy as the first x-ray source. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification