CHONDROCYTE THERAPEUTIC DELIVERY SYSTEM
First Claim
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1. A method for modifying an environment of a target cell associated with a disorder using a genetically altered chondrocyte, comprising:
- providing a housing configured to retain a genetically altered chondrocyte;
providing a genetically altered chondrocyte retained within the housing, the genetically altered chondrocyte altered to express a therapeutic agent;
delivering the housing and genetically altered chondrocyte to the environment of a target cell associated with a disorder; and
expressing the therapeutic agent to a level sufficient to modify the environment surrounding the target cell.
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Abstract
Systems and methods for modifying the environment of target cell using genetically altered chondrocytes are provided. The genetically engineered chondrocytes can be used to express a therapeutic agent in a subject, including in an environment typically associated with chondrocytes and in an environment not typically associated with chondrocytes.
105 Citations
23 Claims
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1. A method for modifying an environment of a target cell associated with a disorder using a genetically altered chondrocyte, comprising:
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providing a housing configured to retain a genetically altered chondrocyte; providing a genetically altered chondrocyte retained within the housing, the genetically altered chondrocyte altered to express a therapeutic agent; delivering the housing and genetically altered chondrocyte to the environment of a target cell associated with a disorder; and expressing the therapeutic agent to a level sufficient to modify the environment surrounding the target cell. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A method for ameliorating a disorder or injury in a subject, comprising:
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providing a housing configured to retain a genetically altered chondrocyte; providing a genetically altered chondrocyte retained within the housing, the genetically altered chondrocyte altered to express a therapeutic agent; delivering the housing and genetically altered chondrocyte into a target region of the subject; and expressing the therapeutic agent in the target region at a level sufficient to ameliorate the disorder. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification