COMPOSITIONS AND METHODS FOR TREATING INFLAMMATION AND AUTO-IMMUNE DISEASES
First Claim
1. A pharmaceutical composition dosage unit comprising a soluble B7-H4 antagonist in an amount effective to reduce or inhibit one or more symptoms of an inflammatory response in an individual in need thereof, and a pharmaceutically acceptable carrier for administration of the antagonist.
2 Assignments
0 Petitions
Accused Products
Abstract
Compositions containing soluble B7-H4 (sH4) antagonists in an amount effective to reduce, inhibit, or mitigate an inflammatory response in an individual and methods for the treatment or prophylaxis of inflammatory disorders and autoimmune diseases or disorders are provided. Soluble H4 has been discovered to interfere with B7-H4 activity including B7-H4'"'"'s activity as an inhibitor of T cell immunity. Thus, interference of sH4 biological activity is an effective method to restore B7-H4 activity and thereby provide an effective method for treating inflammatory diseases or disorders including autoimmune diseases or disorders.
107 Citations
21 Claims
- 1. A pharmaceutical composition dosage unit comprising a soluble B7-H4 antagonist in an amount effective to reduce or inhibit one or more symptoms of an inflammatory response in an individual in need thereof, and a pharmaceutically acceptable carrier for administration of the antagonist.
-
8. A method for treating or inhibiting one or more symptoms of an inflammatory response in an individual in need thereof comprising
administering to the individual an antagonist of soluble B7-H4 in an amount effective to reduce or inhibit the one or more symptoms of the inflammatory response in the individual.
-
16. A method for assessing the severity or risk of developing an autoimmune disease or disorder comprising
obtaining a biological sample from an individual; -
determining levels of soluble B7-H4 in the sample, and comparing the levels of soluble B7-H4 in the sample to levels in a normal control or controls with levels known to be indicative of a severity or risk of developing an autoimmune disease or disorder. - View Dependent Claims (17)
-
-
18. A method for treating or inhibiting an inflammatory response comprising
a) removing biological fluid from an individual; -
b) removing soluble B7-H4 from the biological fluid to produce treated biological fluid; c) returning the treated biological fluid to the individual. - View Dependent Claims (19, 20, 21)
-
Specification