PD-1 SPECIFIC ANTIBODIES AND USES THEREOF
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Accused Products
Abstract
One aspect of the present disclosure provides antibodies that can act as agonists of PD-1, thereby modulating immune responses regulated by PD-1. Another aspect of the disclosure provides compositions comprising PD-1 specific antibodies and their use in methods of down regulating the immune response. These methods can be practiced on any subject, including humans or animals. Anti-PD-1 antibodies disclosed herein may be used, in another aspect of the invention, to detect PD-1 or its fragments in a biological sample. The amount of PD-1 detected may be correlated with the expression level of PD-1, and associated with the activation status of immune cells (e.g., activated T cells, B cells, and/or monocytes) in the subject.
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Citations
78 Claims
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1-56. -56. (canceled)
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57. An isolated antibody selected from:
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a) a monoclonal antibody produced by the hybridoma clone 10 or the hybridoma clone 2; b) a monoclonal antibody that binds to the same epitope as the monoclonal antibody produced by the hybridoma clone 10 or the hybridoma clone 2; c) a bispecific, humanized, single-chain, chimeric, synthetic or recombinant antibody that binds to the same epitope as the antibody produced by the hybridoma clone 10 or the hybridoma clone 2; d) an antigen binding fragment that binds to the same epitope as the monoclonal antibody produced by clone 10 or clone 2; e) an antibody or antigen binding fragment according to any one of a) through d), wherein said antibody or antigen binding fragment has a dissociation constant of 0.04 sec−
1 to 2.0 sec−
1;an isolated antibody or antigen binding fragment competing with an antibody comprising;
SEQ ID NO;
2 and SEQ ID NO;
4;
or SEQ ID NO;
8 and SEQ ID NO;
10 for binding to PD-1;g) an antibody or antigen binding fragment according to
1), which binds to the same PD-1 epitope as an antibody comprising;
SEQ ID NO;
2 and SEQ ID NO;
4;
or SEQ ID NO;
8 and SEQ ID NO;
10;h) an antibody according to c), wherein said antibody comprises the clone 2 Vk and VH CDRs of SEQ ID NOs;
15, 16, 17, 19, 20 and i) SEQ ID NO;
18;
or ii) amino acids 6-10 of SEQ ID NO;
18 or the clone 10 CDRs of SEQ ID NOs;
21, 22, 23, 25, 26 and i) SEQ ID NO;
24;
or ii) amino acids 6-11 of SEQ ID NO;
24;
ori) an isolated antibody or antigen binding fragment comprising;
SEQ ID NO;
2 and SEQ ID NO;
4;
or SEQ ID NO;
8 and SEQ ID NO;
10. - View Dependent Claims (58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78)
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Specification