Methods and Compositions Relating to the Regulation of Apoptosis by MUC1 and BH3-Containing Proapoptotic Proteins
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Abstract
This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or immune cell growth. The invention provides methods of inhibiting interactions between MUC1 and BH3-containing proapoptotic proteins, methods of inhibiting MUC1 expression, and methods of promoting apoptosis. Also provided are screening methods for compounds that inhibit interactions between MUC1 and BH3-containing proapoptotic proteins and pharmaceutical compositions of the same.
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Citations
58 Claims
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1-25. -25. (canceled)
- 26. An in vivo method of inhibiting an interaction between MUC1 and a BH3-containing proapoptotic protein, the method comprising delivering to a subject a compound that inhibits the interaction between MUC1 and a BH3-containing proapoptotic protein.
- 44. An in vivo method of promoting apoptosis in a cell, the method comprising identifying a subject as one having a cancer comprising one or more cells expressing a BH3-containing proapoptotic protein, and delivering to the subject a compound that inhibits MUC1.
- 50. An in vivo method of promoting apoptosis in a cell, the method comprising identifying a subject as one having a cancer comprising one or more cells expressing a BH2-containing antiapoptotic protein, and delivering to the subject a compound that inhibits the interaction between MUC1 and a BH3-containing proapoptotic protein, wherein the BH3-containing proapoptotic protein is capable of binding to the BH2-containing antiapoptotic protein.
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52. An in vivo method of promoting apoptosis in a cell, the method comprising identifying a subject as having a cancer comprising one or more cells expressing MUC1, and delivering to the subject an inhibitor of a BH2-containing antiapoptotic protein.
- 53. An in vivo method of promoting apoptosis in a cell, the method comprising identifying a subject as one having a inflammatory condition mediated by one or more inflammatory cells expressing a BH3-containing proapoptotic protein, and delivering to the subject a compound that inhibits MUC1.
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58-62. -62. (canceled)
Specification