Materials Comprising Water-Soluble Polymer Particles and Methods of Making and Using Them

• US 20110171282A1
• Filed: 06/19/2008
• Published: 07/14/2011
• Est. Priority Date: 06/19/2007
• Status: Active Grant

• Current Assignee: Rynel, Inc. (Mölnlycke Holding AB)
• Original Assignee: Rynel, Inc. (Mölnlycke Holding AB)
• Inventors: Kennedy, T. Scott
• Granted Patent: US 8,962,027 B2
• Time in Patent Office: Days
• US Class Current: 424/443
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: C08F 2/18 Suspension polymerisation
• CPC Class Codes: C08G 18/10 Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
• CPC Class Codes: C08G 18/14 Manufacture of cellular products
• CPC Class Codes: C08G 18/302 Water
• CPC Class Codes: C08G 2101/00 Manufacture of cellular products
• CPC Class Codes: C08J 2375/04 Polyurethanes
• CPC Class Codes: C08J 2471/00 Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
• CPC Class Codes: C08J 9/0061 characterized by the use of several polymeric components

Abstract

One aspect of the invention relates to new materials for storing, protecting, selectively releasing, and applying active ingredients (e.g. pharmaceuticals and other chemicals). In certain embodiments, the invention provides materials impregnated with water-soluble polymer particles which contain active ingredients which may be selectively released and dispensed in response to contact with water or another liquid.

Claims

1. A material comprising a substrate, a foam, and a plurality of water-soluble polymer particles;

wherein each of the plurality of water-soluble polymer particles comprise an active ingredient, the foam permeates the substrate, and the water-soluble polymer particles are trapped within the substrate by the foam.

3. The material of claim 1 or 2, wherein the substrate is a non-woven material.

7. The material of claim 1 or 2, wherein the foam is a polyurethane foam prepared from water, a surfactant, and a prepolymer mixture.

8. The material of claim 7, wherein the surfactant is selected from the group consisting silicone-based surfactants, polysiloxane-polyoxyalkylene block copolymers, cyanoalkylpolysiloxanes, alkylpolysiloxanes, polydimethylsiloxane, polyoxyalkylene-modified dimethylpolysiloxanes, salts of fatty acids, salts of sulfuric acid esters, salts of phosphoric acid esters and sulfonates, Triton materials, Tergitol materials, Emerest materials, Emulgade materials, Cocamide MEA, Pluronic materials, Brij 72 and sodium alpha olefin sulfonate.

10. The material of claim 7, wherein the prepolymer mixture selected from the group consisting of branched alkyl-isocyanate-capped poly(ether), unbranched alkyl-isocyanate-capped poly(ether), branched aromatic-isocyanate-capped poly(ether), unbranched aromatic-isocyanate-capped poly(ether), branched alkyl-isocyanate-capped poly(ether)-poly(ester) copolymer, unbranched alkyl-isocyanate-capped poly(ether)-poly(ester) copolymer, branched aromatic-isocyanate-capped poly(ether)-poly(ester) copolymer, and unbranched aromatic-isocyante-capped poly(ether)-poly(ester) copolymer.

11. The material of claim 7, wherein the prepolymer mixture is toluene diisocyanate terminated or capped polyethylene glycol with less than 6% available unreacted NCO groups and with an isocyanate functionality less than 2.

12. The material of claim 1 or 2, wherein the water-soluble polymer particles are prepared from one or more monomers selected from the group consisting of styrene, vinyl acetate, ethylene, ethylene oxide, acrylonitrile, acrylic acid, acrylamide, maleic anhydride, monovinyl silicon compounds, ethyl vinyl ether, chlorostyrene vinyl pyridine, vinylidene chloride, butyl vinyl ether, methyl methacrylate and 2-ethylhexyl acrylate.

14. The material of claim 1 or 2, wherein the active ingredient is selected from the group consisting of silver salts, silver nitrate, silver sulfate, nafcillin, nystatin, undecylenic acid, salicylic acid, salicylsulfonic acid, nicotinic acid, adenosine diphosphate, chlorhexidine, bacitracin, chlortetracycline, gentamycin, kanamycin, neomycin B, polymyxin B, streptomycin, tetracycline, amphotericin B, clotrimazole, miconazole, cysteine, glycine, threonine, lidocaine, trypsin, streptokinase, plasmin, streptodornase, deoxyribonuclease, epinephrine, serotonin, amphotericin B, clotrimazole, miconazole, and chlorohexidine digluconate.

15. The material of claim 1 or 2, wherein the water-soluble particles containing the active agent form at least 10% of the material by weight.

2. A material comprising a substrate, two layers of foam, and a plurality of water-soluble polymer particles;

wherein each of the plurality of water-soluble polymer particles comprise an active ingredient, the substrate is sandwiched between the two layers of foam, and the water-soluble polymer particles are trapped within the substrate by the two layers of foam.

4-6. -6. (canceled)

9. (canceled)

13. (canceled)

16-19. -19. (canceled)

20. A method for preparing a water-soluble polymer particle impregnated material comprising the steps of:

coating a substrate with a plurality of water-soluble polymer particles;

stirring a mixture comprising water, surfactant, and a prepolymer mixture;

pouring the mixture on the water-soluble polymer particle coated substrate, thereby permeating the substrate, and

allowing the mixture to cure into a foam, thereby forming a water-soluble polymer particle impregnated material.

21. A method for preparing a water-soluble polymer particle impregnated material comprising the steps of:

stirring a first mixture comprising water, surfactant, and a prepolymer mixture;

pouring the first mixture onto a surface;

placing a substrate on top of the first mixture and allowing the first mixture to cure into a first foam layer, thereby binding the substrate and the first foam layer;

coating the side of the substrate which is not bound to the first foam layer with a plurality of water-soluble polymer particles;

stirring a second mixture comprising water, surfactant, and a prepolymer mixture;

pouring the second mixture onto a surface containing the water-soluble polymer particles and allowing the second mixture to cure, thereby trapping the plurality of water-soluble polymer particles within the material and forming a water-soluble polymer particle impregnated material.

22-38. -38. (canceled)