SELF-ASSEMBLING TISSUE MODULES
First Claim
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1. A method for in vitro producing a tissue construct comprising:
- a) combining living cells to form supracellular aggregates using spatial confinement;
b) combining two or more of the supracellular aggregates in a mold or on a biomaterial;
c) applying conditions that induce self-assembly within the combined supracellular aggregates to obtain the tissue construct; and
d) applying conditions that induce tissue morphogenesis in the tissue construct.
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Abstract
The invention relates to a new approach to constructing cellular aggregates in vitro and their use in methods for producing 3D-tissue constructs in a modular way.
In particular, the invention is directed to a method for in vitro producing a tissue construct comprising:
- a) combining living cells to form supracellular aggregates using spatial confinement;
- b) combining two or more of the supracellular aggregates in a mold or on a biomaterial;
- c) applying conditions that induce self-assembly within the combined supracellular aggregates to obtain the tissue construct; and
- d) applying conditions that induce tissue morphogenesis in the tissue construct.
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22 Claims
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1. A method for in vitro producing a tissue construct comprising:
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a) combining living cells to form supracellular aggregates using spatial confinement; b) combining two or more of the supracellular aggregates in a mold or on a biomaterial; c) applying conditions that induce self-assembly within the combined supracellular aggregates to obtain the tissue construct; and d) applying conditions that induce tissue morphogenesis in the tissue construct. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification