INJECTION SYSTEMS

• US 20110172634A1
• Filed: 03/21/2011
• Published: 07/14/2011
• Est. Priority Date: 11/30/2000
• Status: Active Grant

• Current Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Original Assignee: Valeritas, Inc. (Zealand Pharma A/S)
• Inventors: NISHTALA, Vasu, DIMEGLIO, Ciro, LIPSON, David, GONNELLI, Robert R.
• Granted Patent: US 8,500,681 B2
• Time in Patent Office: Days
• US Class Current: 604/500
• CPC Class Codes: A61M 5/2046 Media being expelled from injector by gas generation, e.g. explosive charge
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2459 upon internal pressure increase, e.g. pierced or burst A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
• CPC Class Codes: A61M 5/46 having means for controlling depth of insertion
• CPC Class Codes: A61M 5/484 Regulating injection pressure

Abstract

The invention in general relates to various injection systems and devices that can be used, for example, in needleless injection systems for human, and for domestic and farm animals. In certain embodiments, the invention provides an injection system comprising: an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; a housing defining a second cavity, the housing different than the injector; a first movable member between the first cavity and the second cavity, wherein the first movable member is configured to transfer a fluid from the second cavity to the first cavity; and wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant.

Claims

1. An injection system, comprising:

an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; and

a housing inside the injector and defining a second cavity, the housing different than the injector,

wherein the injection system is configured to transfer a fluid from the second cavity to the first cavity.

2. The system of claim 1, wherein the injector is formed of a first material, and the housing is formed of a second material different than the first material.

3. The system of claim 2, wherein the first material comprises a polymer.

4. The system of claim 2, wherein the second material comprises a glass.

5. The system of claim 1, further comprising a first movable member between the first cavity and the second cavity.

6. The system of claim 5, wherein the first movable member defines a lumen.

7. The system of claim 5, further comprising a second movable member between the first movable member and the second cavity.

8. The system of claim 7, wherein the first-movable member is configured to engage with me second movable member such that the first cavity is in fluid communication with the second cavity.

9. The system of claim 5, wherein the first movable member is configured to be substantially stationary until the first movable member is moved by a propellant of the injection system.

10. The system of claim 5, wherein the first movable member comprises a tab configured to separate from the first movable member at a predetermined force.

11. The system of claim 10, wherein the tab is engaged with the injector.

12. The system of claim 1, wherein the injector and the housing are substantially coaxial.

13. The system of claim 1, wherein the second cavity is defined by the housing and two movable members.

14. The system of claim 1, further comprising an injector cap connectable to the injector, the injector cap configured to move distally to transfer the fluid from the second cavity to the first cavity.

15. The system of claim 14, wherein the injector cap is connectable to the injector by a threaded connection.

16. The system of claim 1, further comprising a charge cup in the injector.

17. The system of claim 16, further comprising a charge in the charge cup.

18. The system of claim 17, wherein the charge comprises at least two discrete materials.

19. The system of claim 18, wherein the at least two discrete materials have different combustion characteristics.

20. The system of claim 1, wherein the second cavity is defined by the housing and a movable member.

21. The system of claim 20, wherein the movable member is formed of two different materials.

22. The system of claim 20, wherein the movable member comprises a rubber.

23. A method, comprising:

providing an injection system, comprising;

an injector defining a first cavity in fluid communication with an orifice configured for needleless injection; and

a housing inside the injector and defining a second cavity, the housing different than the injector; and

reducing the volume of the second cavity to transfer a fluid from the second cavity to the first cavity.

24. The method of claim 23, further comprising flowing the fluid through a movable member between the first and second cavities.

25. The method of claim 23, further comprising piercing a member between the first and second cavities.

26. The method of claim 23, wherein the injection system further comprises an injector cap connectable to the injector, and reducing the volume comprises moving the injector cap toward the orifice.

27. The method of claim 26, wherein moving the injector cap comprises twisting the injector cap.

28. The method of claim 23, further comprising moving the fluid through the orifice charge.

29. The method of claim 28, wherein the charge comprises at least two discrete materials.

30. The method of claim 29, wherein the at least two discrete materials have different combustion characteristics.