WEARABLE DRUG DELIVERY DEVICE INCLUDING INTEGRATED PUMPING AND ACTIVATION ELEMENTS

• US 20110172645A1
• Filed: 01/08/2010
• Published: 07/14/2011
• Est. Priority Date: 01/08/2010
• Status: Abandoned Application

• Current Assignee: FluGen, Inc., Ratio, Inc.
• Original Assignee: FluGen, Inc., Ratio, Inc.
• Inventors: Smith, Garrick D.S., Moga, Benjamin J., Chase, Kent B.
• Application Number:
  US12/684,832
• Publication Number:
  US 20110172645A1
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: A61K 9/0021 Intradermal administration, e.g. through microneedle arrays, needleless injectors mechanical aspects A61M
• CPC Class Codes: A61K 9/703 characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61M 5/14224 Diaphragm type
• CPC Class Codes: A61M 5/14248 of the skin patch type
• CPC Class Codes: A61M 5/14586 pressurised by means of a flexible diaphragm
• CPC Class Codes: A61M 5/14593 the diaphragm being actuated by fluid pressure

Abstract

A drug delivery device for delivering a drug to a subject is provided. The drug delivery device includes a housing, a drug reservoir supported by the housing containing the drug and a hollow microneedle supported by the housing. The hollow microneedle is moveable from an inactive position to an activated position, wherein, when the hollow microneedle is moved to the activated position, the tip portion of the hollow microneedle is configured to penetrate the skin of the subject. The drug delivery device includes a channel having an input in communication with the drug reservoir and an output in communication with the hollow microneedle. The channel provides fluid communication between the drug reservoir and the hollow microneedle, such that the drug is permitted to flow from the drug reservoir through the channel and through the hollow microneedle. The channel moves from a first position to a second position as the hollow microneedle moves from the inactive position to the activated position, and the position of the drug reservoir relative to the housing remains fixed as the hollow microneedle moves from the inactive position to the activated position.

Claims

1. A drug delivery device for delivering a drug to a subject, the device comprising:

a housing;

a drug reservoir supported by the housing, the drug reservoir containing the drug;

a hollow microneedle supported by the housing, the hollow microneedle moveable from an inactive position to an activated position, wherein, when the hollow microneedle is moved to the activated position, the tip portion of the hollow microneedle is configured to penetrate the skin of the subject; and

a channel having an input in communication with the drug reservoir and an output in communication with the hollow microneedle, wherein the input of the channel is in fluid communication with the drug reservoir when the hollow microneedle is in the inactive position, wherein the channel provides fluid communication between the drug reservoir and the hollow microneedle, such that the drug is permitted to flow from the drug reservoir through the channel and through the hollow microneedle;

wherein the channel moves from a first position to a second position as the hollow microneedle moves from the inactive position to the activated position, and further wherein the position of the drug reservoir relative to the housing remains fixed as the hollow microneedle moves from the inactive position to the activated position.

2. The device of claim 1, further comprising a channel arm extending between the drug reservoir and the hollow microneedle, the channel formed at least in part of the material of the channel arm, wherein the channel arm is integral with the drug reservoir.

3. The device of claim 2, wherein the channel arm comprises a flexible material and the channel arm bends as the channel is moved from the first position to the second position.

4. The device of claim 2, wherein the channel arm includes a microneedle attachment portion coupled to the hollow microneedle in both the inactive position and the activated position.

5. The device of claim 2, further comprising a reservoir base and a flexible film coupled to the reservoir base such that an inner surface of the reservoir base and an inner surface of the flexible film define the drug reservoir.

6. The device of claim 5, wherein the channel arm includes a depression running the length of the channel arm, wherein the flexible film is coupled to the channel arm such that an inner surface of the depression and the inner surface of the flexible film define the channel.

7. The device of claim 6, further comprising a reservoir actuator in contact with the flexible film, the reservoir actuator configured to increase pressure within the drug reservoir to move the drug from the drug reservoir through the channel and through the tips of the hollow microneedle to deliver the drug to the skin of the subject.

8. The device of claim 7, wherein the reservoir actuator is a hydrogel configured to expand when placed in contact with an activation fluid.

9. The device of claim 8, further comprising an activation fluid reservoir and a fluid distribution element positioned between the activation fluid reservoir and the hydrogel.

10. The device of claim 9, wherein the activation fluid is water and the fluid distribution element is a hydrophilic wick configured to transmit water from the activation fluid reservoir to the hydrogel.

11. The device of claim 1, further comprising a microneedle actuator comprising stored energy, the microneedle actuator located within the housing and configured to release stored energy to cause the hollow microneedle to move from the inactive position to the activated position.

12. The device of claim 11, wherein the microneedle actuator is a torsion rod.

13. A device for delivering a liquid drug into the skin of a subject, the device comprising:

a housing;

a drug reservoir coupled to the housing;

a conduit coupled to and integral with the drug reservoir;

a microneedle coupled to the conduit; and

a microneedle actuator located within the housing, wherein the microneedle actuator is configured to impart kinetic energy to the microneedle to drive the microneedle into the skin of the subject upon activation.

14. The device of claim 13, further comprising an activation control moveable from a first position to a second position to cause activation of the microneedle.

15. The device of claim 14, wherein the microneedle actuator is a torsion rod.

16. The device of claim 15, wherein the torsion rod is supported by a latch bar when the activation control is in the first position.

17. The device of claim 16, wherein movement of the activation control from the first position to the second position moves the latch bar to release the torsion rod.

18. The device of claim 17, wherein the activation control is a button, the button including a top wall and at least one engagement surface extending from the lower surface of the top wall, wherein as the button is moved from the first position to the second position the engagement surface engages the latch bar to release the torsion rod.

19. A wearable drug delivery device for delivering a liquid drug into the skin of a subject, the device comprising:

a housing;

an attachment element for attaching the drug delivery device to the skin of the subject;

a drug reservoir for storing a dose of the liquid drug, the drug reservoir supported by the housing;

a microneedle array including a plurality of hollow microneedles, each of the hollow microneedles including a tip portion and a central channel extending through the tip portion, the microneedle array moveable from an inactive position to an activated position, wherein, when the microneedle array is moved to the activated position, the tip portions of the hollow microneedles are configured to penetrate the skin of the subject;

a drug channel extending from the drug reservoir and coupled to the microneedle array such that the drug reservoir is in fluid communication with the tip portions of the hollow microneedles;

a channel arm extending between the drug reservoir and the microneedle array, the drug channel formed at least in part of the material of the channel arm, wherein the channel arm comprises a flexible material and the channel arm bends as the channel arm is moved from a first position to a second position as the microneedle array moves from the inactive position to the activated position, and further wherein the channel arm is integral with the drug reservoir;

a microneedle attachment element coupling the microneedle array to the channel arm in both the inactive position and the activated positions; and

a microneedle actuator comprising stored energy, the microneedle actuator located within the housing, the microneedle actuator configured to transfer the stored energy to the microneedle array to cause the microneedle array to move from the inactive position to the activated position.

20. The device of claim 19, wherein the microneedle actuator is a torsion rod.