HYDROGEL IMPLANT WITH SUPERFICIAL PORES
First Claim
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1. A biocompatible hydrogel configured for implantation into a joint, comprising:
- a top surface configured for attachment to a patient'"'"'s native tissue;
a bottom surface generally opposite of the top surface;
a depth defined between the top surface and the bottom surface;
superficial pores located within about 1 millimeter of the top surface of the hydrogel;
wherein the superficial pores do not extend throughout an entire depth of the hydrogel;
wherein said superficial pores enhance osteoblast differentiation and permit proliferation of osteoblasts; and
wherein the hydrogel is load-bearing.
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Abstract
Implantable biomaterials, particularly hydrogel substrates with porous surfaces, and methods for enhancing the compatibility of biomaterials with living tissue, and for causing physical attachment between biomaterials and living tissues are provided. Also provided are implants suitable for load-bearing surfaces in hard tissue repair, replacement, or augmentation, and to methods of their use. One embodiment of the invention relates to an implantable spinal disc prosthesis.
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Citations
19 Claims
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1. A biocompatible hydrogel configured for implantation into a joint, comprising:
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a top surface configured for attachment to a patient'"'"'s native tissue; a bottom surface generally opposite of the top surface; a depth defined between the top surface and the bottom surface; superficial pores located within about 1 millimeter of the top surface of the hydrogel; wherein the superficial pores do not extend throughout an entire depth of the hydrogel; wherein said superficial pores enhance osteoblast differentiation and permit proliferation of osteoblasts; and wherein the hydrogel is load-bearing. - View Dependent Claims (2, 3, 4, 5, 7, 8, 9, 10)
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11. A load bearing hydrogel implant comprising:
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a first surface having a plurality of superficial pores thereon, said first surface being configured for attachment to a patient'"'"'s native joint tissue; wherein said superficial pores are located at or near the first surface; wherein said superficial pores do not extend throughout said hydrogel; wherein the hydrogel is configured for implantation into a joint; wherein the superficial pores have an average cross-section of between about 1 and 100 micrometers; and wherein the pores are within about 1 millimeter of the hydrogel surface. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19)
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Specification