NOVEL DOSAGE FORM OF PALIPERIDONE AND PROCESS FOR PREPARING THE SAME
First Claim
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1. ) An extended release composition of paliperidone for oral administration comprising an active ingredient and at least one matrixing agent in a ratio of 1:
- 1 to 1;
20 respectively.
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Abstract
The present invention relates to an extended release composition of paliperidone for oral administration comprising paliperidone and at least one matrixing agent. The said extended release composition maintains desired therapeutic drug effect over a prolonged period of time and thereby reduces the side effects resulting due to excess drug blood plasma concentration. Further, the invention also relates to process for the preparation of an extended release oral composition of paliperidone.
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Citations
10 Claims
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1. ) An extended release composition of paliperidone for oral administration comprising an active ingredient and at least one matrixing agent in a ratio of 1:
- 1 to 1;
20 respectively. - View Dependent Claims (2, 3, 4, 5, 6, 7)
- 1 to 1;
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8. ) A process for the preparation of an extended release composition of paliperidone for oral administration which comprises of an active ingredient and at least one matrixing agent;
- wherein the process comprises of the following steps;
a) Blending paliperidone and at least one intra-granular matrixing agent to form a first blend, b) Granulating the first blend using a binding solution to form granulates, c) Blending the granulates obtained in step b) with at least one extra-granular matrixing agent, and d) Compressing the second blend obtained in step c) into tablet. - View Dependent Claims (9, 10)
- wherein the process comprises of the following steps;
Specification