Tubular nanostructure targeted to cell membrane
First Claim
Patent Images
1. A tubular nanostructure comprising:
- a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane, andat least one ligand configured to bind one or more cognates on the membrane.
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Abstract
Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.
64 Citations
84 Claims
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1. A tubular nanostructure comprising:
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a hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane, and at least one ligand configured to bind one or more cognates on the membrane. - View Dependent Claims (2, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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3-5. -5. (canceled)
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43. A composite tubular nanostructure comprising:
two or more nanotubes wherein at least one nanotube includes a hydrophobic surface region, each hydrophobic surface region flanked by two hydrophilic surface regions configured to form a pore in a lipid bilayer membrane. - View Dependent Claims (44, 46, 47, 48, 49, 50, 51, 52, 57, 59, 60, 66, 67, 69, 83)
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45. (canceled)
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53-56. -56. (canceled)
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58. (canceled)
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61-65. -65. (canceled)
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68. (canceled)
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70-82. -82. (canceled)
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84-119. -119. (canceled)
Specification