FLUORESCENT MAGNETIC NANOPARTICLES AND PROCESS OF PREPARATION
First Claim
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1. A nanoparticle comprising a core particle, wherein the core particle comprises a magnetic material and a fluorescent material, and wherein the nanoparticle has a particle size less than about 1 micrometer.
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Abstract
This invention provides nanometer-sized fluorescent magnetic particles and processes of making them. The nanoparticle has a core particle comprising a magnetic material and a fluorescent material, and the particle size is less than about 1 micrometer. The nanoparticles can be coated with an inorganic or organic layer and can be surface-modified. The nanoparticles can be used in many biological assays.
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Citations
56 Claims
- 1. A nanoparticle comprising a core particle, wherein the core particle comprises a magnetic material and a fluorescent material, and wherein the nanoparticle has a particle size less than about 1 micrometer.
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2-3. -3. (canceled)
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10-11. -11. (canceled)
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35-47. -47. (canceled)
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48. A process of preparing a nanoparticle comprising fluorescent magnetic particles coated with silica, which process comprises:
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a) dispersing nanometer-sized magnetic particles and nanometer-sized fluorescent particles in an alcohol; b) adding de-ionized water and ammonia having a concentration of 28% to the mixture of step a) at a temperature ranging from about 20°
C. to about 80°
C.; andc) stirring the mixture of step b) after adding n-ethyl silicate (TEOS) for a period of time ranging from about 0.5 hour to about 8 hours to obtain the nanoparticle. - View Dependent Claims (49, 52, 53, 56)
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50-51. -51. (canceled)
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54-55. -55. (canceled)
Specification