DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT
First Claim
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1. A method comprising the steps of:
- (a) providing a microfluidic system comprising one or more channels;
(b) providing within the one or more channels a carrier fluid, a first plug, and a second plug, wherein the first and second plugs each are immiscible with the carrier fluid and wherein the first plug moves at a first velocity and the second plug moves at a second velocity faster than the first velocity when they are within a common channel of the one or more channels such that a distance between the first and second plugs decreases over time; and
(c) merging the first and second plugs into a merged plug when the second plug catches up to the first plug.
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Abstract
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
120 Citations
22 Claims
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1. A method comprising the steps of:
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(a) providing a microfluidic system comprising one or more channels; (b) providing within the one or more channels a carrier fluid, a first plug, and a second plug, wherein the first and second plugs each are immiscible with the carrier fluid and wherein the first plug moves at a first velocity and the second plug moves at a second velocity faster than the first velocity when they are within a common channel of the one or more channels such that a distance between the first and second plugs decreases over time; and (c) merging the first and second plugs into a merged plug when the second plug catches up to the first plug. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification