Bioprinted Nanoparticles and Methods of Use
First Claim
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1. A process for manufacturing complex structure comprising:
- designing a printable structure via a computer-operable software application;
converting the designed structure into a heterogeneous material and multi-part assembly model; and
printing the designed structure using a device comprising a plurality of differentiated, specialized nozzles, wherein at least one of the nozzles is specialized for the deposition of at least one material comprising a magnetic particle.
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Abstract
The present invention provides compositions and methods that combine the initial patterning capabilities of a direct cell printing system with the active patterning capabilities of magnetically labeled cells, such as cells labeled with superparamagnetic nanoparticles. The present invention allows for the biofabrication of a complex three-dimensional tissue scaffold comprising bioactive factors and magnetically labeled cells, which can be further manipulated after initial patterning, as well as monitored over time, and repositioned as desired, within the tissue engineering construct.
141 Citations
27 Claims
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1. A process for manufacturing complex structure comprising:
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designing a printable structure via a computer-operable software application; converting the designed structure into a heterogeneous material and multi-part assembly model; and printing the designed structure using a device comprising a plurality of differentiated, specialized nozzles, wherein at least one of the nozzles is specialized for the deposition of at least one material comprising a magnetic particle. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A multi-nozzle biopolymer deposition apparatus comprising:
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a data processing system which processes a designed scaffold model and converts it into a layered process tool path; a motion control system driven by the layered process tool path; and a material delivery system comprising a plurality of differentiated, specialized nozzles for simultaneously depositing a plurality of biopolymers having different viscosities, thereby constructing a scaffold from the designed scaffold model, wherein at least one of the nozzles deposits at least one magnetically labeled material, - View Dependent Claims (19, 20, 21, 22, 23, 24)
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25. A system for generating a biocompatible structure comprising:
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designing a printable structure via a computer-operable software application; converting the designed structure into a heterogeneous material and multi-part assembly model; printing the designed structure using a device comprising a plurality of differentiated, specialized nozzles, wherein at least one of the nozzles is specialized for the deposition of at least one material comprising a magnetic particle; and applying a magnetic field to reposition the at least one material comprising the magnetic particle after its deposition. - View Dependent Claims (26, 27)
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Specification