DEVICE AND METHOD FOR PRESSURE-DRIVEN PLUG TRANSPORT
First Claim
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1. A method comprising the steps of:
- providing a microfluidic system comprising one or more channels;
providing within the one or more channels a carrier fluid comprising an oil and at least one plug substantially surrounded by the carrier fluid, wherein the plug comprises reagents sufficient for an autocatalytic reaction including a first species of molecule in a concentration such that the plug contains no more than a single molecule of the first species; and
conducting an autocatalytic reaction such that the single molecule is amplified.
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Abstract
The present invention provides microfabricated substrates and methods of conducting reactions within these substrates. The reactions occur in plugs transported in the flow of a carrier-fluid.
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Citations
15 Claims
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1. A method comprising the steps of:
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providing a microfluidic system comprising one or more channels; providing within the one or more channels a carrier fluid comprising an oil and at least one plug substantially surrounded by the carrier fluid, wherein the plug comprises reagents sufficient for an autocatalytic reaction including a first species of molecule in a concentration such that the plug contains no more than a single molecule of the first species; and conducting an autocatalytic reaction such that the single molecule is amplified. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification