NEURAL PROTEINS AS BIOMARKERS FOR NERVOUS SYSTEM INJURY AND OTHER NEURAL DISORDERS
First Claim
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1. A kit comprising:
- (a) a substrate for holding a sample isolated from a subject;
(b) an agent that specifically interacts with ubiquitin C-terminal hydrolase L1 (UCH-L1);
(c) an optional additional agent that specifically interacts with at least one additional protein biomarkers upon contact with said sample; and
(d) printed instructions for reacting the agent and the optional additional agent with the sample or a portion of the sample for diagnosing a neural injury or neuronal disorder in the subject.
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Abstract
The present invention identities biomarkers that are diagnostic of nerve cell injury and/or neuronal disorders. Detection of different biomarkers of the invention are also diagnostic of the degree of severity of nerve injury, the cell(s) involved in the injury, and the subcellular localization of the injury.
20 Citations
31 Claims
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1. A kit comprising:
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(a) a substrate for holding a sample isolated from a subject; (b) an agent that specifically interacts with ubiquitin C-terminal hydrolase L1 (UCH-L1); (c) an optional additional agent that specifically interacts with at least one additional protein biomarkers upon contact with said sample; and (d) printed instructions for reacting the agent and the optional additional agent with the sample or a portion of the sample for diagnosing a neural injury or neuronal disorder in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of detecting a neural injury or neuronal disorder in a subject comprising:
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collecting a sample of a bodily fluid or a tissue in contact with neural tissue from the subject; and analyzing said sample or a fraction thereof for an amount of ubiquitin C-terminal hydrolase L1 (UCH-L1) associated with the neural injury or neuronal disorder; optionally analyzing a sample of the fluid or the tissue for at least one additional protein biomarker associated with the neural injury and/or neuronal disorder. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification