Compositions for Enhancing the Production of PPAR and/or PPAR-Associated Factors

• US 20110178008A1
• Filed: 03/14/2011
• Published: 07/21/2011
• Est. Priority Date: 07/09/2004
• Status: Abandoned Application

• Current Assignee: Meiji Holdings Company Limited
• Original Assignee: Meiji Holdings Company Limited
• Inventors: Takeda, Eiji, Arai, Hidekazu, Sasaki, Hajime
• Application Number:
  US13/047,244
• Publication Number:
  US 20110178008A1
• Time in Patent Office: Days
• US Class Current: 514/6.7
• CPC Class Codes: A23L 27/33 containing sugars or derivatives
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/685 one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61K 31/7016 Disaccharides, e.g. lactose, lactulose lactobionic acid A61K31/7032
• CPC Class Codes: A61K 36/28 Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 36/535 Perilla (beefsteak plant)
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/50 for increasing or potentiating the activity of insulin

Abstract

The present inventors focused on certain nutritional compositions known to have activity of controlling blood glucose levels. These foods were administered to rats for long periods, and real-time PCR was used to analyze the expression of genes associated with lipid metabolism in the liver and adipose tissues. As a result, the present inventors found that the expression of the PPARα gene is enhanced by these foods, and that this is accompanied by suppressed expression of fatty acid synthase and enhanced expression of a group of PPARα target genes associated with fatty acid metabolism. The present inventors also confirmed the effect of these foods in enhancing the expression of PPARγ and adiponectin, and discovered that these foods have the activity of enhancing the production of PPAR and PPAR-associated factors.

Claims

1. A method for restoring insulin sensitivity, which comprises the step of administering to a patient in need of such treatment, a nutritional composition for enhancing the production of a PPAR and/or PPAR-associated factor, wherein the composition comprises proteins, fats, and carbohydrates such that proteins account for 10% to 25% of its energy, fats account for 10% to 35% of its energy, and carbohydrates account for 40% to 60% of its energy, and wherein oleate esters account for 60% to 90% of the energy in the fats, and palatinose and/or trehalose account for 60% to 100% of the energy in the carbohydrates

2. The method of claim 1, wherein the PPAR is a PPARα

and/or a PPARγ

.

3. The method of claim 1, wherein the PPAR is a PPARγ

.

4. The method of claim 1, wherein the PPAR-associated factor is adiponectin.

5. The method of claim 1, wherein the composition comprises at least one fat selected from a milk phospholipid, a soybean lecithin, a high oleic sunflower oil, and a perilla oil.