VIRTUAL ULTRASONIC SCISSORS

• US 20110178541A1
• Filed: 09/13/2009
• Published: 07/21/2011
• Est. Priority Date: 09/12/2008
• Status: Abandoned Application

• Current Assignee: Slender Medical Ltd.
• Original Assignee: Slender Medical Ltd.
• Inventors: Azhari, Haim
• Application Number:
  US13/061,269
• Publication Number:
  US 20110178541A1
• Time in Patent Office: Days
• US Class Current: 606/167
• CPC Class Codes: A61N 2007/0065 Concave transducers
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: A61N 2007/027 with multiple foci created simultaneously
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

Apparatus is provided, which includes at least first and second focused ultrasonic transducers, which are arranged facing each other, and a controllable energy source. The energy source is configured to activate the focused ultrasonic transducers to simultaneously generate respective first and second focused ultrasound beams having respective first and second focal zones located in close proximity to each other. Other embodiments are also described.

Claims

1. Apparatus comprising:

at least first and second focused ultrasonic transducers, which are arranged facing each other; and

a controllable energy source, which is configured to activate the focused ultrasonic transducers to simultaneously generate respective first and second focused ultrasound beams having respective first and second focal zones located in close proximity to each other.

2. The apparatus according to claim 1, wherein the apparatus is configured to generate the respective beams such that a distance between respective centers of the respective focal zones is between 25% and 200% of the sum of a greatest diameter of the first focal zone and a greatest diameter of the second focal zone.

5. The apparatus according to claim 1, wherein the apparatus is configured to generate the respective beams having respective opposing acoustic forces such that the beams together generate mechanical shear forces between the focal zones.

6. The apparatus according to claim 1, wherein the apparatus is configured to generate the respective beams such that the beams tear a material disposed between the focal zones.

7. The apparatus according to claim 1, wherein the apparatus is configured to generate the respective beams such that the beams do not increase a temperature of a material, having a specific heat of 4.18 J/(g*K), disposed between the focal zones, by more than 20°

C.

8. The apparatus according to claim 7, wherein the apparatus is configured to generate the respective beams such that the beams do not cause substantial cavitation in the material.

9. The apparatus according to claim 1, further comprising a support structure, to which the focused ultrasonic transducers are coupled.

10. The apparatus according to claim 1, wherein the apparatus is configured to generate the respective beams such that the beams have parallel respective axes.

11. The apparatus according to claim 10, wherein the apparatus is configured to generate the respective beams such that a distance between the respective axes is between 25% and 200% of the sum of a greatest diameter of the first focal zone and a greatest diameter of the second focal zone.

13. The apparatus according to claim 1, wherein the focused ultrasonic transducers comprise respective phased arrays, and wherein the energy source is configured to activate the arrays to generate the respective focused ultrasound beams.

14. The apparatus according to claim 13, wherein the energy source is configured to activate each of the arrays to steer its respective focused ultrasound beam in a plurality of directions during respective time periods.

15. The apparatus according to claim 1, wherein the energy source is configured to mechanically steer the respective focused ultrasound beams.

16. The apparatus according to claim 1, wherein the focused ultrasonic transducers together comprise a phased array arranged in a ring, and wherein the energy source is configured to activate a first subgroup of the elements to generate the first focused ultrasound beam, and a second subgroup of the elements, different from the first subgroup, to generate the second focused ultrasound beam.

17. The apparatus according to claim 1, wherein the focused ultrasound beams are shock waves, and wherein the focused ultrasonic transducers are configured to simultaneously generate the shock waves having the respective first and second focal zones in close proximity to each other.

51. The apparatus according to claim 1, wherein the apparatus is configured to perform a calibration procedure, in which the apparatus initially generates the first and second ultrasound beams such that the respective focal zones coincide, and thereafter adjusts a location of at least one of the focal zones such that the focal zones are in close proximity to each other, rather than coincide.

3-4. -4. (canceled)

12. (canceled)

18. A method comprising:

identifying a target tissue region in a body of a subject; and

destroying at least a portion of the target tissue region by simultaneously generating, in opposing directions, at least first and second focused ultrasound beams having respective first and second focal zones in close proximity to each other within the target tissue region.

19. The method according to claim 18, wherein generating comprises generating the beams such that a distance between respective centers of the respective focal zones is between 25% and 200% of the sum of a greatest diameter of the first focal zone and a greatest diameter of the second focal zone.

22. The method according to claim 18, wherein generating comprises generating the respective beams having respective opposing acoustic forces such that the beams together generate mechanical shear forces between the focal zones.

23. The method according to claim 18, wherein generating comprises generating the respective beams such that the beams tear tissue between the focal zones.

26. The method according to claim 18, wherein generating comprises generating the respective beams such that the respective focused ultrasound beams have respective axes that are parallel to each other.

27. The method according to claim 26, wherein generating comprises generating the respective beams such that a distance between the respective axes is between 25% and 200% of the sum of a greatest diameter of the first focal zone and a greatest diameter of the second focal zone.

28. The method according to claim 18, wherein generating comprises:

positioning at least first and second focused ultrasonic transducers facing each other in a vicinity of the target tissue region, wherein the focused ultrasonic transducers include respective phased arrays; and

activating the respective phased arrays of the first and second focused ultrasonic transducers to simultaneously generate the first and second focused ultrasound beams, respectively.

32. The method according to claim 18, wherein generating comprises steering the respective focused ultrasound beams.

34. The method according to claim 18, wherein generating the first and second focuses ultrasound beams comprises generating shock waves having the respective first and second focal zones in close proximity to each other.

52. The method according to claim 18, wherein generating comprises performing a calibration procedure, which comprises:

initially generating the first and second ultrasound beams such that the respective focal zones coincide; and

thereafter adjusting a location of at least one of the focal zones such that the focal zones are in close proximity to each other, rather than coincide.

20-21. -21. (canceled)

24-25. -25. (canceled)

29-31. -31. (canceled)

33. (canceled)

35. Apparatus comprising:

at least first and second focused ultrasonic transducers, which are arranged facing in generally a same direction; and

a controllable energy source, which is configured to activate the focused ultrasonic transducers to simultaneously generate respective first and second focused ultrasound beams having respective first and second focal zones, which are located in close proximity to each other, and have oppositely-signed pressures.

36. The apparatus according to claim 35, wherein the apparatus is configured to generate the respective beams such that a distance between respective centers of the respective focal zones is between 25% and 200% of the sum of a greatest diameter of the first focal zone and a greatest diameter of the second focal zone.

39. The apparatus according to claim 35, wherein the apparatus is configured to generate the respective beams having respective opposing acoustic forces such that the beams together generate mechanical shear forces between the focal zones.

40. The apparatus according to claim 35, wherein the apparatus is configured to generate the respective beams such that the beams tear a material disposed between the focal zones.

41. The apparatus according to claim 35, wherein the focused ultrasound beams are shock waves, and wherein the focused ultrasonic transducers are configured to simultaneously generate the shock waves having the respective first and second focal zones in close proximity to each other.

42. The apparatus according to claim 35, wherein the energy source is configured to activate the focused ultrasonic transducers to generate arbitrary waveforms.

53. The apparatus according to claim 35, wherein the apparatus is configured to perform a calibration procedure, in which the apparatus initially generates the first and second ultrasound beams such that the respective focal zones coincide, and thereafter adjusts a location of at least one of the focal zones such that the focal zones are in close proximity to each other, rather than coincide.

37-38. -38. (canceled)

43. A method comprising:

identifying a target tissue region in a body of a subject; and

destroying at least a portion of the target tissue region by simultaneously generating, in non-opposing directions, at least first and second focused ultrasound beams having respective first and second focal zones, which are in close proximity to each other within the target tissue region, and which have oppositely-signed pressures.

44. The method according to claim 43, wherein generating comprises generating the beams such that a distance between respective centers of the respective focal zones is between 25% and 200% of the sum of a greatest diameter of the first focal zone and a greatest diameter of the second focal zone.

47. The method according to claim 43, wherein generating comprises generating the respective beams having respective opposing acoustic forces such that the beams together generate mechanical shear forces between the focal zones.

48. The method according to claim 43, wherein generating comprises generating the respective beams such that the beams tear tissue between the focal zones.

49. The method according to claim 43, wherein generating the first and second focuses ultrasound beams comprises generating shock waves having the respective first and second focal zones in close proximity to each other.

50. The method according to claim 43, wherein generating comprises generating the beams having arbitrary waveforms.

54. The method according to claim 43, wherein generating comprises performing a calibration procedure, which comprises:

initially generating the first and second ultrasound beams such that the respective focal zones coincide; and

thereafter adjusting a location of at least one of the focal zones such that the focal zones are in close proximity to each other, rather than coincide.

45-46. -46. (canceled)