Imaging Agents for Detecting Neurological Disorders
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Abstract
Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.
38 Citations
34 Claims
- 1. A compound of Formula (V):
- 18. A compound of Formula (Va):
- 24. A compound of Formula (Vb):
- 27. A compound of Formula Vb′
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32. A method for imaging and detection of neurofibrillary tangles and/or senile plaques in a brain tissue, the method comprising treating the tissue with a compound of formula (V) and measuring a radioactive signal or fluorescent intensity.
Specification