ANTI FGF23 ANTIBODY AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
First Claim
Patent Images
1. A method of treating diseases having excessive activity of FGF23, comprising administrating an antibody or a functional fragment thereof to a subject, wherein the antibody or the functional fragment has at least any one of CDR1 shown by SEQ ID NO:
- 40, CDR2 shown by SEQ ID NO;
41, and CDR3 shown by SEQ ID NO;
42 as heavy chain CDR and binds to FGF23.
1 Assignment
0 Petitions
Accused Products
Abstract
To provide an antibody against FGF23 and a pharmaceutical composition such as a preventive or therapeutic agent which can prevent or treat by suppressing an action of FGF23 by using the antibody. An antibody or its functional fragment against human FGF23 produced by hybridoma C10 (Accession No. FERM BP-10772).
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Citations
11 Claims
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1. A method of treating diseases having excessive activity of FGF23, comprising administrating an antibody or a functional fragment thereof to a subject, wherein the antibody or the functional fragment has at least any one of CDR1 shown by SEQ ID NO:
- 40, CDR2 shown by SEQ ID NO;
41, and CDR3 shown by SEQ ID NO;
42 as heavy chain CDR and binds to FGF23. - View Dependent Claims (2, 6, 8)
- 40, CDR2 shown by SEQ ID NO;
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3. A method of treating diseases having excessive activity of FGF23, comprising administrating an antibody or a functional fragment thereof to a subject, wherein the antibody or the functional fragment has at least any one of CDR1 shown by SEQ ID NO:
- 43, CDR2 shown by SEQ ID NO;
44, and CDR3 shown by SEQ ID NO;
45 as light chain CDR and binds to FGF23. - View Dependent Claims (4, 10)
- 43, CDR2 shown by SEQ ID NO;
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5. A method of treating diseases having excessive activity of FGF23, comprising administrating an antibody or a functional fragment thereof to a subject, wherein the antibody or the functional fragment has all of CDR1 shown by SEQ ID NO:
- 40, CDR2 shown by SEQ ID NO;
41, and CDR3 shown by SEQ ID NO;
42 as heavy chain CDR and all of CDR1 shown by SEQ ID NO;
43, CDR2 shown by SEQ ID NO;
44, and CDR3 shown by SEQ ID NO;
45 as light chain CDR and binds to FGF23.
- 40, CDR2 shown by SEQ ID NO;
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7. A method of increasing serum phosphorous concentration, comprising administrating an antibody or a functional fragment thereof to a subject, wherein the antibody or the functional fragment has at least any one of CDR1 shown by SEQ ID NO:
- 40, CDR2 shown by SEQ ID NO;
41, and CDR3 shown by SEQ ID NO;
42 as heavy chain CDR and binds to FGF23.
- 40, CDR2 shown by SEQ ID NO;
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9. A method of treating diseases having excessive activity of FGF23, comprising administrating an antibody or a functional fragment thereof to a subject, wherein the antibody or the functional fragment has at least any one of CDR1 shown by SEQ ID NO:
- 43, CDR2 shown by SEQ ID NO;
44, and CDR3 shown by SEQ ID NO;
45 as light chain CDR and binds to FGF23.
- 43, CDR2 shown by SEQ ID NO;
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11. A method of treating diseases having excessive activity of FGF23, comprising administrating an antibody or a functional fragment thereof to a subject, wherein the antibody or the functional fragment has all of CDR1 shown by SEQ ID NO:
- 40, CDR2 shown by SEQ ID NO;
41, and CDR3 shown by SEQ ID NO;
42 as heavy chain CDR and all of CDR1 shown by SEQ ID NO;
43, CDR2 shown by SEQ ID NO;
44, and CDR3 shown by SEQ ID NO;
45 as light chain CDR and binds to FGF23.
- 40, CDR2 shown by SEQ ID NO;
Specification