Nitric oxide sensors and systems

• US 20110182970A1
• Filed: 11/30/2010
• Published: 07/28/2011
• Est. Priority Date: 10/30/2007
• Status: Abandoned Application

• Current Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Original Assignee: Gearbox LLC (Intellectual Ventures LLC)
• Inventors: Stordal, Leif T., Ishikawa, Muriel Y., Wood, Lowell L. JR., Hyde, Roderick A.
• Application Number:
  US12/928,029
• Publication Number:
  US 20110182970A1
• Time in Patent Office: Days
• US Class Current: 424/445
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: G01N 33/0037 NOx
• CPC Class Codes: Y02A 50/20 Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters

Abstract

The present disclosure relates to nitric oxide sensors and systems.

Claims

1-161. -161. (canceled)

162. A dressing comprising:

at least one substrate with at least one portion that is alterably permeable;

one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

163. The dressing of claim 162, wherein the at least one substrate with at least one portion that is alterably permeable comprises:

at least one polymeric substrate with at least one portion that is alterably permeable.

164. The dressing of claim 162, wherein the at least one substrate with at least one portion that is alterably permeable comprises:

at least one substrate with at least one layer that is alterably permeable.

165. The dressing of claim 162, wherein the at least one substrate with at least one portion that is alterably permeable comprises:

at least one substrate with at least one portion that is alterably permeable in response to biodegradation of one or more materials forming the at least one substrate.

166. The dressing of claim 162, wherein the at least one substrate with at least one portion that is alterably permeable comprises:

at least one substrate with at least one portion that is alterably permeable in response to modification of porosity.

167. The dressing of claim 162, wherein the at least one substrate with at least one portion that is alterably permeable comprises:

at least one substrate with at least one portion that is alterably permeable in response to modification of electrical charge distribution.

168. The dressing of claim 162, wherein the at least one substrate with at least one portion that is alterably permeable comprises:

at least one substrate with at least one portion that is alterably permeable in response to one or more signals of at least one control unit.

169. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more nitric oxide donors impregnated within the at least one polymeric substrate and configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

170. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate and by strength of one or more electric fields.

171. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more topically deliverable nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

172. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more liposomal nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

173. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more nitric oxide donor compositions configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

174. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more polymerized nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

175. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more photolyzable nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

176. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more chemically activated nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

177. The dressing of claim 162, wherein the one or more nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate comprises:

one or more chargeably activated nitric oxide donors configured to be released from the at least one portion of the at least one substrate at one or more rates determined at least partially by permeability of the at least one portion of the at least one substrate.

178. The dressing of claim 162, further comprising:

at least one nitric oxide impermeable layer associated with at least a portion of the at least one substrate.

179. The dressing of claim 162, further comprising:

one or more agents for activating at least some of the one or more nitric oxide donors released from the at least one portion of the at least one substrate.

180. The dressing of claim 162, further comprising:

one or more therapeutic agents.

181. The dressing of claim 162, further comprising:

at least one user interface.

182. The dressing of claim 162, further comprising:

one or more sensors configured for detecting nitric oxide.

183. The dressing of claim 162, further comprising:

one or more sensors configured for detecting at least one microbe.

184. The dressing of claim 162, further comprising:

at least one control unit configured for controllably altering permeability of the at least one portion of the at least one substrate.

185. The dressing of claim 162, further comprising:

at least one control unit configured for controllably altering permeability of the at least one portion of the at least one substrate in response to user input.

186. The dressing of claim 162, further comprising:

at least one control unit configured for controllably altering permeability of the at least one portion of the at least one substrate in response to at least one signal of one or more sensors.

187. The dressing of claim 162, further comprising:

at least one control unit configured for controllably altering permeability of the at least one portion of the at least one substrate in response to one or more program instructions.