PHARMACEUTICAL DOSAGE FORM FOR THE SITE-SPECIFIC DELIVERY OF MORE THAN ONE ACTIVE PHARMACEUTICAL INGREDIENT
First Claim
1. A pharmaceutical dosage form for the site-specific delivery of more than one API, the dosage form comprising at least one outer layer containing at least one API for delivery to a first site in a human or animal body and at least one inner layer containing at least one API for delivery to a second site in the human or animal body, each layer having characteristics which, when subjected to specific stimuli unique to its delivery site, enable the release in said site of said API.
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Abstract
This invention relates to a pharmaceutical dosage form for the site specific delivery of more than one active pharmaceutical ingredient to different sites in the human or animal body in the gastrointestinal tract. The dosage form has an outer polymeric layer incorporating a first active pharmaceutical ingredient which reacts to stimuli specific in the stomach, degrades, and releases the first active pharmaceutical ingredient in the stomach for absorption. The dosage form also has at least one inner polymeric layer incorporating a second active pharmaceutical ingredient which, once the outer layer has degraded, passes into the intestine where the polymers of the second layer degrade to release the second active pharmaceutical ingredient. The dosage form may have additional layers each incorporating active pharmaceutical ingredients for release in different portions of the intestine depending on the nature of the polymers.
13 Citations
91 Claims
- 1. A pharmaceutical dosage form for the site-specific delivery of more than one API, the dosage form comprising at least one outer layer containing at least one API for delivery to a first site in a human or animal body and at least one inner layer containing at least one API for delivery to a second site in the human or animal body, each layer having characteristics which, when subjected to specific stimuli unique to its delivery site, enable the release in said site of said API.
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73. (canceled)
Specification