Compositions and methods for therapeutic delivery with microorganisms
First Claim
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1. A system comprising:
- at least one computing device;
at least one delivery device configured to retain and dispense at least one composition to at least one environmental medium; and
a recordable medium including one or more instructions that when executed on a computing device cause the computing device to regulate dispensing of at least a portion of the at least one composition,wherein the at least one composition includes at least one modified microorganism including at least one heterologous genetic element encoding at least one environmental medium treatment agent; and
at least one genetic element inducible to initiate death of the at least one modified microorganism.
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Abstract
Certain embodiments disclosed relate to compositions, including therapeutic compositions, methods, devices, and systems that include modified microorganisms including at least one genetic element encoding at least one therapeutic agent or environmental treatment agent.
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Citations
62 Claims
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1. A system comprising:
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at least one computing device; at least one delivery device configured to retain and dispense at least one composition to at least one environmental medium; and a recordable medium including one or more instructions that when executed on a computing device cause the computing device to regulate dispensing of at least a portion of the at least one composition, wherein the at least one composition includes at least one modified microorganism including at least one heterologous genetic element encoding at least one environmental medium treatment agent; and
at least one genetic element inducible to initiate death of the at least one modified microorganism. - View Dependent Claims (2, 3, 4, 5, 6, 7, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28, 29, 33, 34)
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8-9. -9. (canceled)
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26-27. -27. (canceled)
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30-32. -32. (canceled)
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35. A computer-implemented method comprising:
one or more instructions for regulating dispensing of at least one composition from at least one delivery device to at least one environmental medium, the at least one composition including at least one modified microorganism including at least one heterologous genetic element encoding at least one environmental medium treatment agent; and
at least one genetic element inducible to initiate death of the at least one modified microorganism.- View Dependent Claims (36, 37, 40, 41, 42, 43, 44, 45, 46, 47, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
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38-39. -39. (canceled)
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48. (canceled)
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62-80. -80. (canceled)
Specification