DEVICE AND METHODS FOR LIQUID CRYSTAL-BASED BIOAGENT DETECTION
First Claim
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1. A method for detecting the presence of a bioagent in a sample, comprising:
- (a) forming a membrane containing a polymerized target for a bioagent at an interface between a liquid crystal and an aqueous phase; and
(b) introducing a bioagent into the aqueous phase wherein interaction of the bioagent and polymerized target leads to a change in the orientational order of the liquid crystal, said orientational change indicating the presence of the bioagent.
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Abstract
The present invention provides liquid crystal-based devices and methods for bioagent detection. In certain aspects, the present invention is directed to devices and methods utilizing liquid crystals and membranes containing polymerized targets that can report the presence of bioagents including, but not limited to, enzymes, antibodies, and toxins.
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8 Claims
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1. A method for detecting the presence of a bioagent in a sample, comprising:
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(a) forming a membrane containing a polymerized target for a bioagent at an interface between a liquid crystal and an aqueous phase; and (b) introducing a bioagent into the aqueous phase wherein interaction of the bioagent and polymerized target leads to a change in the orientational order of the liquid crystal, said orientational change indicating the presence of the bioagent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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