Superior Control of Blood Glucose in Diabetes Treatment
First Claim
1. A method of reducing postprandial glucose excursions in a patient with an insulin-related disorder comprising:
- selecting a patient with an insulin-related disorder;
administering a dose of an insulin composition comprising fumaryl diketopiperazine in a form suitable for pulmonary administration in proximity to beginning a meal, wherein the patient'"'"'s total insulin exposure (INS-AUC0-y, 3<
y<
6 hours) from said dose does not substantially exceed that produced by an appropriate subcutaneous dose of insulin; and
reducing the postprandial glucose excursions relative to treatment with the appropriate subcutaneous dose of insulin.
4 Assignments
0 Petitions
Accused Products
Abstract
Methods related to the treatment of diabetes and improving the control of blood glucose levels are provided. In particular, methods are provided for effectively reducing postprandial glucose excursions while reducing the incidence of clinically significant late postprandial hypoglycemia by administered an insulin composition in a form suitable for pulmonary administration. Additionally, methods for effectively reducing post-prandial glucose excursions while reducing the incidence of clinically significant late postprandial hypoglycemia by administered an insulin composition in a form suitable for pulmonary administration along with a long-acting basal insulin.
147 Citations
20 Claims
-
1. A method of reducing postprandial glucose excursions in a patient with an insulin-related disorder comprising:
-
selecting a patient with an insulin-related disorder; administering a dose of an insulin composition comprising fumaryl diketopiperazine in a form suitable for pulmonary administration in proximity to beginning a meal, wherein the patient'"'"'s total insulin exposure (INS-AUC0-y, 3<
y<
6 hours) from said dose does not substantially exceed that produced by an appropriate subcutaneous dose of insulin; andreducing the postprandial glucose excursions relative to treatment with the appropriate subcutaneous dose of insulin. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A method of treating a patient with an insulin related disorder comprising:
-
administering an insulin composition comprising a diketopiperazine and insulin in a form suitable for pulmonary administration from between from 10 minutes prior to beginning a meal to 30 minutes after beginning a meal; wherein said composition induces a maximum glucose elimination rate in said patient within 60 minutes of administration. - View Dependent Claims (12, 13, 14, 15, 16)
-
-
17. A method of treating a patient with an insulin related disorder comprising:
-
administering an insulin composition comprising a diketopiperazine and insulin in a form suitable for pulmonary administration from between 10 minutes prior to beginning a meal to 30 minutes after beginning a meal; wherein said composition induces a lower coefficient of variation at the 95% confidence interval of insulin exposure, (INS-AUCo-x, x≦
3 hours) or glucose elimination ((GIR-)AUCo-x, x≦
3 hours), in said patient than subcutaneously administered insulin, where the total insulin exposure [INS-AUCo-y, 3≦
y≦
6] is substantially similar. - View Dependent Claims (18, 19, 20)
-
Specification