Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy) phenylmethyl)carbamide and its Tartrate Salt and Crystalline Forms
First Claim
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1. Anhydrous crystalline form B of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide tartrate of formula IV,
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Abstract
Disclosed herein are methods for synthesizing N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide. Also disclosed herein is the hemi-tartrate salt of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and methods for obtaining the salt. Further disclosed are various crystalline forms of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)-phenylmethyl)carbamide and its hemi-tartrate salt including various polymorphs and solvates.
1 Citation
13 Claims
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1. Anhydrous crystalline form B of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide tartrate of formula IV,
- View Dependent Claims (2, 3)
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4. Crystalline form B of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide tartrate of formula IV,
- View Dependent Claims (5, 6, 7, 8)
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9. Crystalline form B of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide tartrate of formula IV,
- View Dependent Claims (10, 11, 12, 13)
Specification