METHOD AND SYSTEM FOR MONITORING HYDRATION

• US 20110184261A1
• Filed: 01/26/2010
• Published: 07/28/2011
• Est. Priority Date: 01/26/2010
• Status: Active Grant

• Current Assignee: ChromoLogic
• Original Assignee: ChromoLogic
• Inventors: Menon, Naresh
• Granted Patent: US 8,452,362 B2
• Time in Patent Office: Days
• US Class Current: 600/318
• CPC Class Codes: A61B 3/0008 provided with illuminating means A61B3/117 takes precedence; goniolenses used for laser treatment A61F9/009; illuminating means for optical instruments G02B27/00
• CPC Class Codes: A61B 3/10 Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/4869 Determining body composition

Abstract

A device for measuring a hydration status based on an analyte concentration in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light, wherein the processor determines a hydration status of the subject based on the analyte concentration level and reference data.

Claims

1. A device for measuring a hydration status based on an analyte concentration level in a subject, the device comprising:

a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye;

an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye;

an analyzer configured for analyzing the detected reflected light; and

a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light, wherein the processor determines the hydration status of the subject based on the analyte concentration level and reference data.

2. The device of claim 1, wherein the reference data corresponds to a hydration level in an anterior region of a healthy eye.

3. The device of claim 1, wherein the illumination spectrum comprises wavelengths ranging from about 200 nm to about 900 nm.

4. The device of claim 1, wherein the angle at which the eye is illuminated ranges from about 70 degrees to about 90 degrees.

5. The device of claim 1, further comprising a modulator configured for modulating the incident light to reduce extraneous effects.

6. The device of claim 1, wherein the analyzer comprises an optical spectrometer.

7. The device of claim 1, wherein the analyzer comprises an interferometer.

8. The device of claim 1, wherein the light source comprises an incoherent light source.

9. The device of claim 1, wherein the analyte concentration level comprises a Na concentration level.

10. A method for measuring a hydration status based on an analyte concentration in a subject, the method comprising the steps of:

irradiating at least a portion of an anterior region of an eye with incident light with a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye;

detecting reflected light from the at least a portion of the anterior region;

analyzing the reflected light;

determining the analyte concentration level based on the analyzed reflected light; and

determining a hydration status of the subject based on the analyte concentration level and reference data.

11. The method of claim 10, wherein the reference data corresponds to analyte concentration levels in the anterior chamber of a healthy eye.

12. The method of claim 10, wherein the illumination spectrum comprises wavelengths ranging from about 200 nm to about 900 nm.

13. The method of claim 10, further comprising modulating the incident light to reduce extraneous effects.

14. The method of claim 10, wherein the analyzing the reflected light comprises analyzing the reflected light with an optical spectrometer.

15. The method of claim 10, wherein the analyzing the reflected light comprises analyzing the reflected light with an interferometer.

16. The method of claim 10, wherein the incident light comprises incoherent light.

17. The method of claim 10, wherein the illumination spectrum comprises wavelengths ranging from about 200 nm to about 900 nm.

18. The method of claim 10, wherein the angle at which the eye is illuminated ranges from about 70 degrees to about 90 degrees.

19. The method of claim 10, wherein the analyte concentration level comprises a Na concentration level.