HEART FAILURE DETECTOR

• US 20110184301A1
• Filed: 09/30/2008
• Published: 07/28/2011
• Est. Priority Date: 09/30/2008
• Status: Abandoned Application

• Current Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories Incorporated)
• Inventors: Blomqvist, Andreas, Holmström, Nils, Broomé, Michael
• Application Number:
  US13/121,844
• Publication Number:
  US 20110184301A1
• Time in Patent Office: Days
• US Class Current: 600/516
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/349 Detecting specific parameters of the electrocardiograph cycle
• CPC Class Codes: A61B 5/366 Detecting abnormal QRS complex, e.g. widening
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone

Abstract

In an apparatus and method for detecting incipient heart failure of a patient. Impedance signals reflecting volume changes of the right ventricle and/or the right atrium of a heart of the patient are obtained. The impedance signals are processed to determine a first impedance parameter substantially reflecting a volume of the right ventricle, and a heart failure status is determined based on the first impedance parameter, wherein a decreasing first impedance parameter is determined to be an indication of a deterioration of the heart failure status.

Claims

1. A heart failure detector for detecting incipient heart failure of a patient comprising:

an impedance measuring unit that obtains impedance signals reflecting volume changes of the right ventricle of a heart of said patient, said impedance measuring unit being connectable to at least two electrodes adapted to be located in said right ventricle such that volume changes of said right ventricle and/or said right atrium are reflected by said impedance signals;

a computerized impedance processing unit configured to receive said impedance signals from said impedance measuring unit and to process said impedance signals to determine a first impedance parameter substantially reflecting a volume of the right ventricle; and

a computerized heart failure status determining unit configured to determine a heart failure status based on said first impedance parameter, wherein a decreasing first impedance parameter is determined to be an indication of a deterioration of said heart failure status.

2. The heart failure detector according to claim 1, further comprising a QRS detector circuit connectable to said electrodes, said QRS detector detecting occurrence of cardiac events in the cardiac cycle, and said impedance processing unit synchronizing detected cardiac events with said impedance signals and processing said impedance signals such that the first impedance parameter reflects an end-systolic volume of the right ventricle.

3. The heart failure detector according to claim 2, wherein

said QRS detector identifies cardiac events in successive QRS complexes;

and

said impedance processing unit being configured to identify a maximum impedance in a time window between to successive QRS complexes, wherein said maximum impedance substantially reflects the end-systolic volume, and to determine said first impedance parameter to be said identified maximum impedance.

4. The heart failure detector according to claim 1, wherein said impedance processing unit is configured to process said impedance signals to determine a second impedance parameter substantially reflecting a difference between diastolic and systolic volume.

5. The heart failure detector according to claim 1, wherein said impedance processing unit is configured to process said impedance signals to determine a second impedance parameter substantially reflecting a right ventricular ejection-fraction.

6. The heart failure detector according to claim 4, wherein said heart failure status determining unit is configured to determine that a heart failure status of said patient is deteriorating if said first impedance parameter has decreased below a predetermined first impedance parameter threshold, and said second impedance parameter has decreased, or if said second impedance parameter remains substantially unchanged.

7. The heart failure detector according to claim 1, wherein

said impedance processing unit is adapted to calculate a rate of change of said first and said second impedance parameter for each cardiac cycle or for a number of cardiac cycles, and

said heart failure status determining unit is configured to determine that a heart failure status of said patient is deteriorating if a rate of change of a decrease of said first impedance parameter is higher than a predetermined threshold, and/or a rate of change of a decrease of said second impedance parameter is higher than a predetermined threshold.

8. The heart failure detector according to claim 1, wherein said at least two electrodes are adapted to be implanted within or at the right ventricle and/or right atrium of said heart, in an electrode configuration selected from the group consisting of a first electrode configuration wherein a first electrode is located in the right atrium, a second electrode is located in the right ventricle, a third electrode located in the right atrium, and a fourth electrode located in the right ventricle, and a second electrode configuration wherein a first electrode and a second electrode both are located in the right ventricle.

9. The heart failure detector according to claim 1, wherein said impedance measuring unit obtains said impedance signals during consecutive cardiac cycles, wherein each impedance signal is obtained in synchronization with a specific cardiac event in respective cardiac cycle, and wherein said impedance processing unit is configured to process said received impedance signal to determine said first impedance parameter to be a mean impedance value of the impedance signals and said second impedance parameter to be a peak-to-peak value of the impedance signal between a cardiac event in two consecutive cardiac cycles.

10. A method for detecting incipient heart failure of a patient comprising:

obtaining impedance signals reflecting volume changes of the

right ventricle of a heart of said patient, using at least two electrodes adapted to be located in said right ventricle such that volume changes of said right ventricle and/or said right atrium are reflected by said impedance signals;

processing said impedance signals to determine a first impedance parameter substantially reflecting a volume of the right ventricle; and

determining a heart failure status based on said first impedance parameter, wherein a decreasing first impedance parameter is determined to be an indication of a deterioration of said heart failure status.

11. The method according to claim 10, further comprising:

detecting the QRS complexes and detecting the occurrence of cardiac events in the cardiac cycle;

synchronizing detected cardiac events with said impedance signals; and

processing said impedance signals such that the first impedance parameter reflects an end-systolic volume of the right ventricle.

12. The method according to claim 11, further comprising:

identifying cardiac events in successive QRS complexes;

identifying a maximum impedance in a time window between to successive QRS complexes, wherein said maximum impedance substantially reflects the end-systolic volume, and

determining said first impedance parameter to be said identified maximum impedance.

13. The method according to claim 10, wherein said step of processing further comprises processing said impedance signals to determine a second impedance parameter substantially reflecting a difference between diastolic and systolic volume.

14. The method according to claim 10, wherein said step of processing further comprises processing said impedance signals to determine a second impedance parameter substantially reflecting a right ventricular ejection-fraction.

16. The method according to claim 10, further comprising:

calculating a rate of change of said first and said second impedance parameters for each cardiac cycle or for a number of cardiac cycles, and

determining that a heart failure status of said patient is deteriorating if a rate of change of a decrease of said first impedance parameter is higher than a predetermined threshold and/or a rate of change of a decrease of said second impedance parameter is higher than a predetermined threshold.

17. The method according to claim 10, further comprising:

obtaining said impedance signals during consecutive cardiac cycles, wherein each impedance signal is obtained in synchronization with a specific cardiac event in respective cardiac cycle, and

processing said impedance signal to determine said first impedance parameter to be a mean impedance value of the impedance signals and said second impedance parameter to be a peak-to-peak value of the impedance signal between a cardiac event in two consecutive cardiac cycles.

15. The method detector according to further comprising determining that a heart failure status of said patient is deteriorating if said first impedance parameter has decreased below a predetermined first impedance parameter threshold, and said second impedance parameter has decreased, or if said second impedance parameter remains substantially unchanged.