Porous composite comprising silicon-substituted hydroxyapatite and ß- tricalcium phosphate, and process for preparing the same

• US 20110185946A1
• Filed: 04/07/2011
• Published: 08/04/2011
• Est. Priority Date: 10/09/2008
• Status: Abandoned Application

• Current Assignee: Metabiomed Company Limited
• Original Assignee: Metabiomed Company Limited
• Inventors: Kim, Min Sung, Ha, Seong Min, Choi, Young Muk
• Application Number:
  US13/066,122
• Publication Number:
  US 20110185946A1
• Time in Patent Office: Days
• US Class Current: 106/286.6
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C04B 2111/00836 for medical or dental applications
• CPC Class Codes: C04B 2235/3208 Calcium oxide or oxide-forming salts thereof, e.g. lime
• CPC Class Codes: C04B 2235/3212 Calcium phosphates, e.g. hydroxyapatite
• CPC Class Codes: C04B 2235/3418 Silicon oxide, silicic acids, or oxide forming salts thereof, e.g. silica sol, fused silica, silica fume, cristobalite, quartz or flint glass constituents C04B2235/36
• CPC Class Codes: C04B 2235/444 Halide containing anions, e.g. bromide, iodate, chlorite
• CPC Class Codes: C04B 2235/447 Phosphates or phosphites calcium phosphates C04B2235/3212, e.g. orthophosphate, hypophosphite
• CPC Class Codes: C04B 2235/656 characterised by specific heating conditions during heat treatment
• CPC Class Codes: C04B 2235/6567 Treatment time
• CPC Class Codes: C04B 2235/80 Phases present in the sintered or melt-cast ceramic products other than the main phase
• CPC Class Codes: C04B 35/447 based on phosphates , e.g. hydroxyapatite
• CPC Class Codes: C04B 38/04 by dissolving-out added substances

Abstract

There are disclosed a porous composite comprising silicon-substituted hydroxyapatite and β-tricalcium phosphate (β-TCP), and a method for preparing the same. The porous composite is prepared by subjecting natural coral to hydrothermal and solvothermal reactions to prepare silicon-substituted hydroxyapatite (Si—HA) and subjecting the Si—HA to a heat treatment process. Thereafter, Si—HA and β-TCP may be mixed in the porous composite. As a result, the porous composite is excellent in biocompatibility and biodegradability. Also, the porous composite functions to maintain the microstructure of coral and is similar to natural bone in terms of composition and shape. Accordingly, the porous composite may be effectively used as a bone tissue repairing material and a bone graft material that can substitute for human hard tissue.

Claims

1. A method for preparing the porous composite, the method comprising:

preparing silicon-substituted hydroxyapatite by subjecting natural coral to hydrothermal reaction in a (NH₄)₂HPO₄ solution, followed by subjecting the hydrothermally reacted coral to solvothermal reaction in a silicon acetate/acetone-saturated solution; and

converting a portion of the silicon-substituted hydroxyapatite into β

-tricalcium phosphate (β

-TCP) by performing a heat treatment process at 800°

C.-1200°

C. for 1-6 hours on the silicon-substituted hydroxyapatite.

2. The method of claim 1, wherein the hydrothermal reaction is performed at 200°

C. for 16-20 hours.

3. The method according to claim 1, wherein the solvothermal reaction is performed at 50°

C.-90°

C. for 30-50 hours.