RADIOPHARMACEUTICAL COMPLEXES
First Claim
Patent Images
1. A complex comprising (a) a radionuclide and (b) a macrocycle comprising (i) a plurality of chelating moieties, (ii) a linker, (iii) a first scaffold moiety and (iv) a second scaffold moiety, wherein each of the chelating moieties is attached to the first scaffold moiety and the second scaffold moiety.
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Accused Products
Abstract
The invention provides compounds such as chelating agents useful in chelating metal ions, particularly radionuclides, to provide metal ion complexes. The invention also provides methods of using the compounds and complexes of the invention, such as in therapeutic and diagnostic applications.
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Citations
81 Claims
- 1. A complex comprising (a) a radionuclide and (b) a macrocycle comprising (i) a plurality of chelating moieties, (ii) a linker, (iii) a first scaffold moiety and (iv) a second scaffold moiety, wherein each of the chelating moieties is attached to the first scaffold moiety and the second scaffold moiety.
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2. (canceled)
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6-7. -7. (canceled)
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9-10. -10. (canceled)
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12-14. -14. (canceled)
- 15. A complex comprising (a) a radionuclide and (b) a chelator comprising (i) a plurality of chelating moieties and (ii) a first scaffold moiety, wherein each of the chelating moieties is attached to the first scaffold moiety and wherein each of the chelating moieties has a structure independently selected from
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17-20. -20. (canceled)
- 22. A complex comprising (a) a radionuclide and (b) a first chelator comprising (i) a plurality of chelating moieties, (ii) a linker and (iii) a first scaffold moiety, wherein each of the chelating moieties is attached to the first scaffold moiety and wherein each of the chelating moieties has a structure independently selected from:
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24-27. -27. (canceled)
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30-38. -38. (canceled)
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42-50. -50. (canceled)
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53-58. -58. (canceled)
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60. (canceled)
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62. (canceled)
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68-70. -70. (canceled)
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81-83. -83. (canceled)
Specification