MEASURING MULTI-ANALYTE SAMPLES USING AN IN-LINE FLOW CELL
First Claim
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1. A method for measuring analytes in a sample, the method comprising:
- flowing a sample containing analytes through a detector;
measuring a measurand of the analytes passing through the detector;
determining a time interval over which the measurand reaches a predetermined quantity; and
diverting a portion of the flowing sample containing the predetermined quantity of the measurand to a sample volume.
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Abstract
Methods and systems for analyzing ratios of analytes within a flowing sample are provided. The flowing sample can be processed in real-time to determine a time interval over which a predetermined amount of a group of analytes passes by a fixed point in a flow cell. The predetermined amount can be routed to a sample container for future processing. The sample can comprise diluted blood and the analytes can comprise a component of hemoglobin, such as A1c, and the total amount of hemoglobin, of which the predetermined amount is metered.
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Citations
30 Claims
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1. A method for measuring analytes in a sample, the method comprising:
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flowing a sample containing analytes through a detector; measuring a measurand of the analytes passing through the detector; determining a time interval over which the measurand reaches a predetermined quantity; and diverting a portion of the flowing sample containing the predetermined quantity of the measurand to a sample volume. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A system for processing a sample, the system comprising:
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a flow cell having an entrance and an exit; a pump system fluidly coupled to the entrance of the flow cell, the pump system configured to move a sample into the flow cell; a detector functionally attached to the flow cell; a first transition valve fluidly coupled to the exit of the flow cell; and a controller configured to determine when a fixed amount of a component of hemoglobin of a portion of the sample has flowed through the flow cell based on a signal from the detector, the controller being configured to switch the first transition valve in order to route the portion of the sample containing the fixed amount of the component of hemoglobin. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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Specification