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GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL pH BUFFERS

  • US 20110190200A1
  • Filed: 06/16/2009
  • Published: 08/04/2011
  • Est. Priority Date: 06/17/2008
  • Status: Active Grant
First Claim
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1. A glucagon peptide with glucagon agonist activity, comprising (i) the amino acid sequence of SEQ ID NO:

  • 1 with one, two, three, or all of the amino acids at positions 16, 20, 21, and 24 substituted with an α



    -disubstituted amino acid, and (ii) a C-terminal alpha carboxylate.

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